Prognostic Factors Influencing the Recurrence Rate and Survival of Patients With Colorectal Cancer: a Single Institution Experience
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- age
研究概览
简要总结
over the past decade colon cancer has emerged as the second most deadly and the third most common type of cancer in the world with increasing incidence in Egypt due to life style and diet change. some research showed relation between colon cancer recurrence and advanced tumor staging. To investigators knowledge, this is the first time to be done in Zagazig University.
Data was collected from records in a retrospective cohort study
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients with newly diagnosed colorectal cancer
- •Age > 18 years old
- •recurrent cases of colorectal cancer
排除标准
- •Pediartric patient less than 18 yr
- •In operable or metastatic cancer colon
- •No other malignancies
结局指标
主要结局
age
时间窗: through study completion, an average of 5 years
age of patients was obtained from medical records
sex
时间窗: through study completion, an average of 5 years
sex of patients was obtained from medical records
tumor grade
时间窗: through study completion, an average of 5 years
tumor grade after resection from pathology report recorded
tumor site
时间窗: through study completion, an average of 5 years
tumor site recorded from operative findings
post operative complications
时间窗: through study completion, an average of 5 years
from records; if there were post operative complication like fecal fistula
site of recurrence
时间窗: through study completion, an average of 5 years
site of tumor recurrence was detected
medical disease
时间窗: through study completion, an average of 5 years
co-existing medical disease was obtained from medical records
occupation
时间窗: through study completion, an average of 5 years
occupation of the patient at time of surgery and if it was changed
previous surgery
时间窗: through study completion, an average of 5 years
previous surgical history was obtained from medical records
CEA
时间窗: through study completion, an average of 5 years
value of carcino-embryonic antigen was recorded
tumor size
时间窗: through study completion, an average of 5 years
tumor size was measured by length x width in cm from records
neoadjuvant therapy
时间窗: through study completion, an average of 5 years
history of neoadjuvant therapy before surgery from records obtained
hand sewen or stappled anastmosis
时间窗: through study completion, an average of 5 years
if there was bowel re-anastmosis after surgery, it was done using a stappler or hand sewing sutures. this was obtained from operative data in patient records
surgical margins of resected tumor
时间窗: through study completion, an average of 5 years
safety margins were assessed from pathological examination under microscopy and recorded in pathology reports, it can be free surgical margins ( no tumor cells) or positive surgical margins( presence of tumor cells)
adjuvant therapy
时间窗: through study completion, an average of 5 years
history of adjuvant therapy post operative obtained from records
diet
时间窗: through study completion, an average of 5 years
diet and dietary life style from history
family history
时间窗: through study completion, an average of 5 years
history taking of family history of cancer disease
soiling by during surgery
时间窗: through study completion, an average of 5 years
by history from records if there was soiling of the field by tumor cells
type of surgery(laparoscopic or open)
时间窗: through study completion, an average of 5 years
type of operation was laparoscopic or open surgery obtained from records
type of resected tumor
时间窗: through study completion, an average of 5 years
type of tumor was recorded from pathology reports
次要结局
未报告次要终点
研究者
Reham Zakaria Mohamed Ahmed
Principal Investigator
Zagazig University