A Randomized Controlled Trial To Compare Application Of Betamethasone Gel And Lignocaine Gel On Endotracheal Tube To Reduce Post Operative Sore Throat, Cough And Hoarseness Of Voice In Laparoscopic Surgeries

After obtaining institutional ethics committee approval and written and informed consent from patients of ASA I to III who will be undergoing surgery under general anaesthesia with endotracheal intubation will be included in this study. Preanesthetic check-up will be carried out in all patients. The patients will be divided into two groups. In Group B—where patients were intubated with endotracheal tube lubricated with 0.05% betamethasone gel; group L—endotracheal tube lubricated with 2% lidocaine jelly. Patients will be kept Nil by mouth (NBM) for 8 hours for solids and 2 hrs for clear liquid before surgery with required medication before surgery Appropriate fluids will be started in preoperative room and will be continued in the operation theatre (OT). After the patient is taken in the operating room, monitors like Pulse oximetry, electrocardiogram, non-invasive blood pressure monitoring, manual blood pressure monitoring and end tidal carbon dioxide monitoring device will be applied and hemodynamic variables will be measured on arrival to the OT and every 5 min thereafter till the end of surgery. Standard anaesthesia technique for induction of general anaesthesia will be used. Patients will be premedicated with injection midazolam 0.02 mg/kg, fentanyl 2 mcg/kg, Lignocaine 2 % (preservative free) 1.5 mg/kg as per protocol. Patients will be induced with IV induction agents and with muscle relaxation as per the case. General anaesthesia will be given by Endotracheal Tube. Before intubation, the endotracheal tube was lubricated from the distal end of the cuff to a distance of 15 cm from the tip using 2.5 ml of 0.05% betamethasone dipropionate gel for patients in group B and with 2.5 ml 2% lidocaine jelly for patients in group L. Immediately after intubation and confirmation of the tube position, the tracheal tube cuff was inflated with room air to keep the intracuff pressure between 18 and 25 mmHg, measured using a tracheal cuff pressure manometer  Anaesthesia will be maintained by O2, AIR and Sevoflurane/ Desflurane. End-tidal CO2 will be maintained between 35 and 40 mm of Hg. Pulse rate, electrocardiogram, NIBP, and oxygen saturation will be monitored continuously throughout the procedure. Before extubation as per the standard protocol adequate anti emetic & analgesic will be given at the end of procedure. Inhale anaesthetic gas will be discontinued. After achieving spontaneous respiration efforts, neuromuscular blockade will be reversed with Inj. Neostigmine 0.05 mg/kg and Inj. Glycopyrrolate 0.01 mg/kg & patient will be extubated. During this process of extubation patient’s responses will be noted. After extubation, patients will be shifted to recovery room for further observation. Post operative period will be defined from time of extubation till 24 hours. The time of tracheal extubation will be noted and assessment of the patients for the incidence and severity of POST, HOV and PEC will be done at 1, 6, 12 and 24 h after extubation.