Assessment of Myocardial Viability Using Multidetector Computed Tomography

Not Applicable

Completed

• Conditions: Myocardial Infarction

• Registration Number: NCT00285064
• Lead Sponsor: Rambam Health Care Campus

Brief Summary

To perform a comprehensive evaluation of multidetector CT myocardial enhancement patterns in patients with an acute ST elevation MI. In particular we plan to assess the relationship between regions with early hypoperfusion and/or late hyperenhancement, and myocardial viability.

Detailed Description

20 patients admitted to ICCU with ST elevation MI, and treated with primary angioplasty on admission, will undergo between day 2 and 7 post-MI the following exams: a) multidetector CT: regular scan plus late scan at 10 minutes, to evaluate coronary arteries, regional function and myocardial enhancement, b) echocardiography with echo-contrast to evaluate function and size of abnormally contracting region and remodeling, c) nuclear studies: rest early and late Thallium SPECT, to evaluate perfusion and viability. At 3 months a second echo will be performed to assess recovery of abnormal segments. The perfusion defects on MSCT will be compared with the other modalities and at 3 months will be used to evaluate recovery of myocardial function i.e. viability. Parameters that will be evaluated include opacity of hypoenhanced segments, ratio of normal to abnormal segments, change in opacity between early and late scans, size and transmurality of hypoenhanced segments, and their relation to regional contraction.

Study Timeline

• Study Start: 2006-01
• Study First Submitted: 2006-01-30
• Study First Submitted QC: 2006-01-30
• Study First Posted: 2006-02-01
• Status Verified: 2007-02
• Primary Completion: 2007-08
• Study Completion: 2008-05
• Last Update Submitted: 2008-10-11
• Last Update Posted: 2008-10-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• acute ST elevation myocardial infarction
• after primary angioplasty

Exclusion Criteria

• iodine allergy
• renal failure
• old MI
• arrhythmia
• inability to perform 20 second breath-hold

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Prediction of viability from myocardial enhancement patterns

Trial Locations

Locations (1)

Rambam Medical Center; 🇮🇱 Haifa, Israel