Cognitive phenotypes in Parkinson's disease: anatomical and functional correlates
- Conditions
- Parkinson's disease1002803710009841
- Registration Number
- NL-OMON39956
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 75
Inclusion Criteria
Idiopathic Parkinson's disease, according to the Queens Square Brain Bank criteria
Age 18 to 80
No other neurological co-morbidity;
Signed informed consent
Exclusion Criteria
Parkinsonian syndromes other than PD
Patients treated by deep brain stimulation.
Pregnant or breastfeeding women
Physical or mental condition is incompatible with the study assessments;
Claustrophobia
Subjects carrying incompatible metallic devices such as pacemakers and certain mechanical valves
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>• Clusters arising from the confirmational cluster analysis<br /><br>• Frequency of the identified cognitive profiles</p><br>
- Secondary Outcome Measures
Name Time Method <p>• Grey matter density in various cortical and subcortical areas, as measured by<br /><br>voxel-based morphometry on the MRI<br /><br>• Connectivity patterns identified by diffusion tensor imagery on the MRI<br /><br>• Localization of the activated brain areas during the resting state MRI<br /><br>• EEG power in the different frequency bands<br /><br>• Source localization of the cortical rhythms recorded with high density EEG<br /><br>(hd-EEG) </p><br>