Comparitive Evaluation of The Antimicrobial Efficacy of Three Herbal Irrigants in Primary Endodontic Infections- A Randomized Clinical Trial
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- To evaluate and compare the antibacterial effectiveness of three herbal irrigants, propolis, chitosan and curcumin with sodium hypochlorite in the primary endodontic infections treated in two visit endodontic treatment.
研究概览
简要总结
This study will aim to evaluate the antibacterial efficacy of three herbal products (propolis, chitosan, and curcumin) as root canal irrigants in comparison to sodium hypochlorite. Sixty patients with primary endodontic infections will be randomly divided into four groups (n=15 each). Preoperative and post-instrumentation bacterial samples will be collected from each canal. Biomechanical preparation will be performed using rotary instruments. Samples will be cultured on Brain Heart Infusion agar, and bacterial colony counts will be determined. Data normality will be assessed using the Shapiro-Wilk test, and inter-group comparisons will be conducted using ANOVA followed by the Tukey post-hoc test to determine statistically significant differences in antibacterial activity between the irrigation solutions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Investigator Blinded
入排标准
- 年龄范围
- 25.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Patient aged 25-65 years.
- •Single rooted teeth with one canal.
- •Single rooted teeth with symptomatic apical periodontitis.
- •Single rooted teeth with irreversible pulpitis.
- •Teeth with necrotic pulp that will be confirmed by pulp sensitivity test.
- •No previous history of endodontic treatment Tooth should have enough coronal tooth structure for rubber dam placement.
排除标准
- •Teeth with unrestorable tooth structure Patients with poor periodontal status.(periodontal pockets 5 mm) Patients with sinus tract, periapical abscess or intraoral swelling.
- •Retreatment cases Presence of a difficult root canal anatomy such as dilaceration, calcified canals, immature apex, root resorption.
- •Patients who had received nsaids or antibiotic treatment in three months before the study.
结局指标
主要结局
To evaluate and compare the antibacterial effectiveness of three herbal irrigants, propolis, chitosan and curcumin with sodium hypochlorite in the primary endodontic infections treated in two visit endodontic treatment.
时间窗: Pre operative and immediately after irrigation
次要结局
- To evaluate & compare the antibacterial efficacy of the three herbal irrigants propolis, chitosan & curcumin with sodium hypochlorite, in the primary endodontic infections treated in two visit endodontic treatment.
研究者
Dr.Jhalak Talwar
SGT Dental College,Hospital and Research Institute