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临床试验/NCT03252652
NCT03252652Unknown不适用

Standardization of Normal Parameters of Cranial Vessels by Using Extra and Trans Cranial Vascular Duplex Among Egyptian Population

Assiut University0 个研究点目标入组 100 人开始时间: 2017年10月最近更新:
适应症

试验速览

阶段
不适用
入组人数
100
主要终点
Normal intimal-medial thickness measured in millimeter

研究概览

简要总结

the study will be carried out to standardize normal parameters of vascular duplex ultrasound of the cranial vessels in the Egyptian population.

详细描述

Atherosclerosis is a major cause of ischemic stroke and a significant proportion of strokes are thromboembolic in nature, arising from atherosclerotic plaques. Several studies have reported racial differences in the severity and distribution of carotid atherosclerosis. In the United States and Western communities, Extra-cranial carotid artery disease was estimated to be responsible for 20-30% of strokes. Little is known about the prevalence and distribution of carotid disease among the populations in the developing countries.

Vascular duplex ultrasound is a useful, cheap and available diagnostic tool for assessing cranial vascular disease. Duplex ultrasound can be highly reliable with proper technique, without the risk of radiation in other imaging modalities, is well tolerated by all patients including those who are claustrophobic in MRI machines, and has much less risks compared to conventional angiography studies.

Although vascular duplex has been used for years yet there is little researches had been done on normal population in the developing countries to collect results and compare it to the parameters that was collected and reviewed in the western developed populations.

The parameters that would be used in this study include both the data collected by static and dynamic duplex scan which are the intimal-medial thickness, the vessels' diameter, peak flow velocity and peak flow volume both systolic and diastolic for either extra- or intra-cranial vessels.

研究设计

研究类型
Observational
观察模型
Other
时间视角
Cross Sectional

入排标准

年龄范围
20 Years 至 60 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Normal subjects between 20-40 years

排除标准

  • Diabetic patients, hypertensive patients, any evidence of vascular disease either peripheral or central, subjects refusing to participate

结局指标

主要结局

Normal intimal-medial thickness measured in millimeter

时间窗: 24 months

Estimation of the intimal-medial thickness for cranial vessels.

Normal peak flow velocity measured in cm/sec

时间窗: 24 months

peak flow velocity both systolic and diastolic for cranial vessels

Normal indices

时间窗: 24 months

pulsatility index and resistance index for cranial vessels

Normal vessels' diameter measured in millimeter

时间窗: 24 months

Estimation of the vessels' diameter

次要结局

  • Early detection of subjects at risk of atherosclerosis(24 months)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Mostafa Mohammed Hamdy Ghazally

principle investigator

Assiut University

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