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Normal Parameters of Cranial Vessels Using Cranial Vascular Duplex Among Egyptian Population

Conditions
Atheroma; Cerebral
Atheroma; Carotid Artery
Atherosclerosis
Atheroma of Cerebral Arteries
Registration Number
NCT03252652
Lead Sponsor
Assiut University
Brief Summary

the study will be carried out to standardize normal parameters of vascular duplex ultrasound of the cranial vessels in the Egyptian population.

Detailed Description

Atherosclerosis is a major cause of ischemic stroke and a significant proportion of strokes are thromboembolic in nature, arising from atherosclerotic plaques. Several studies have reported racial differences in the severity and distribution of carotid atherosclerosis. In the United States and Western communities, Extra-cranial carotid artery disease was estimated to be responsible for 20-30% of strokes. Little is known about the prevalence and distribution of carotid disease among the populations in the developing countries.

Vascular duplex ultrasound is a useful, cheap and available diagnostic tool for assessing cranial vascular disease. Duplex ultrasound can be highly reliable with proper technique, without the risk of radiation in other imaging modalities, is well tolerated by all patients including those who are claustrophobic in MRI machines, and has much less risks compared to conventional angiography studies.

Although vascular duplex has been used for years yet there is little researches had been done on normal population in the developing countries to collect results and compare it to the parameters that was collected and reviewed in the western developed populations.

The parameters that would be used in this study include both the data collected by static and dynamic duplex scan which are the intimal-medial thickness, the vessels' diameter, peak flow velocity and peak flow volume both systolic and diastolic for either extra- or intra-cranial vessels.

Recruitment & Eligibility

Status
UNKNOWN
Sex
All
Target Recruitment
100
Inclusion Criteria
  • Normal subjects between 20-40 years
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Exclusion Criteria
  • Diabetic patients, hypertensive patients, any evidence of vascular disease either peripheral or central, subjects refusing to participate
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Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Normal intimal-medial thickness measured in millimeter24 months

Estimation of the intimal-medial thickness for cranial vessels.

Normal peak flow velocity measured in cm/sec24 months

peak flow velocity both systolic and diastolic for cranial vessels

Normal indices24 months

pulsatility index and resistance index for cranial vessels

Normal vessels' diameter measured in millimeter24 months

Estimation of the vessels' diameter

Secondary Outcome Measures
NameTimeMethod
Early detection of subjects at risk of atherosclerosis24 months

detection of subjects with early atherosclerotic changes for further management

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