Normal Parameters of Cranial Vessels Using Cranial Vascular Duplex Among Egyptian Population
- Conditions
- Atheroma; CerebralAtheroma; Carotid ArteryAtherosclerosisAtheroma of Cerebral Arteries
- Registration Number
- NCT03252652
- Lead Sponsor
- Assiut University
- Brief Summary
the study will be carried out to standardize normal parameters of vascular duplex ultrasound of the cranial vessels in the Egyptian population.
- Detailed Description
Atherosclerosis is a major cause of ischemic stroke and a significant proportion of strokes are thromboembolic in nature, arising from atherosclerotic plaques. Several studies have reported racial differences in the severity and distribution of carotid atherosclerosis. In the United States and Western communities, Extra-cranial carotid artery disease was estimated to be responsible for 20-30% of strokes. Little is known about the prevalence and distribution of carotid disease among the populations in the developing countries.
Vascular duplex ultrasound is a useful, cheap and available diagnostic tool for assessing cranial vascular disease. Duplex ultrasound can be highly reliable with proper technique, without the risk of radiation in other imaging modalities, is well tolerated by all patients including those who are claustrophobic in MRI machines, and has much less risks compared to conventional angiography studies.
Although vascular duplex has been used for years yet there is little researches had been done on normal population in the developing countries to collect results and compare it to the parameters that was collected and reviewed in the western developed populations.
The parameters that would be used in this study include both the data collected by static and dynamic duplex scan which are the intimal-medial thickness, the vessels' diameter, peak flow velocity and peak flow volume both systolic and diastolic for either extra- or intra-cranial vessels.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 100
- Normal subjects between 20-40 years
- Diabetic patients, hypertensive patients, any evidence of vascular disease either peripheral or central, subjects refusing to participate
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Normal intimal-medial thickness measured in millimeter 24 months Estimation of the intimal-medial thickness for cranial vessels.
Normal peak flow velocity measured in cm/sec 24 months peak flow velocity both systolic and diastolic for cranial vessels
Normal indices 24 months pulsatility index and resistance index for cranial vessels
Normal vessels' diameter measured in millimeter 24 months Estimation of the vessels' diameter
- Secondary Outcome Measures
Name Time Method Early detection of subjects at risk of atherosclerosis 24 months detection of subjects with early atherosclerotic changes for further management