Exploring 8-iso Prostaglandin F2α and Adenosine Deaminase Levels in Periodontal Health and Disease

Not Applicable

Completed

• Conditions: Periodontal Diseases
• Interventions: Diagnostic Test: 8-iso Prostaglandin F2α and Adenosine Deaminase

• Registration Number: NCT06236555
• Lead Sponsor: Eda Cetin Ozdemir

Brief Summary

This study aims to assess the diagnostic potential of gingival crevicular fluid (GCF) biomarkers, specifically 8-iso Prostaglandin F2α (8-iso-PGF2α) and adenosine deaminase (ADA), in evaluating periodontal health and disease conditions.

Detailed Description

Conducted as a single-blind, cross-sectional investigation, this study comprised 26 individuals categorized as periodontally healthy, 27 with gingivitis, and 27 diagnosed with periodontitis. The participant pool included individuals with various periodontal concerns who were referred to the Department of Periodontology Clinic at Kahramanmaraş Sütçü İmam University. The classification of periodontal health, gingivitis, and chronic periodontitis adhered to the 2018 criteria outlined by the European Federation of Periodontology

Study Timeline

• Study Start: 2023-10-01
• Primary Completion: 2023-12-31
• Status Verified: 2024-01
• Study Completion: 2024-01-15
• Study First Submitted: 2024-01-24
• Study First Submitted QC: 2024-01-24
• Last Update Submitted: 2024-01-24
• Study First Posted: 2024-02-01
• Last Update Posted: 2024-02-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Patients having more than 20 teeth, minimum age 18, maximum age 65

Exclusion Criteria

• Patients with systemic disease, Active smokers, Pregnant women, individuals with a history of orthodontic treatment, or those who had undergone periodontal treatment, regardless of whether it was surgical or non-surgical (within the last one year),

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Kahramanmaraş Sütçü İmam University	8-iso Prostaglandin F2α and Adenosine Deaminase	Patients who apply to our clinic for routine periodontal treatment will be included in the study.

Primary Outcome Measures

Name	Time	Method
Change in 8-iso Prostaglandin F2α and Adenosine Deaminase scores in periodontal disease	2023	We expect 8-iso Prostaglandin F2α and Adenosine Deaminase scores to increase in periodontal disease.

Trial Locations

Locations (1)

Kahramanmaraş Sütçü İmam University; 🇹🇷 Kahramanmaraş, Oniki Şubat, Turkey