Propofol/Dexmedetomidine Versus Desflurane Effects on Post Hepatectomy Hepatocellular Injury
试验速览
- 阶段
- 早期 1 期
- 状态
- 招募中
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- bilirubin
研究概览
简要总结
This study will compare the effects of propofol/dexmedetomidine versus desflurane for maintenance of general anesthesia on hepatocellular injury in patients undergoing partial hepatectomy.
详细描述
Postoperative impairment of liver function is common after hepatectomy. It may be caused by surgical trauma, loss of hepatic mass, stress response, hepatic oxygen deprivation, infection and drug toxicity.
Anesthetic agents used in general anesthesia for liver surgery have a big effect on hepatic blood flow, oxygen delivery and liver function This study will compare the effects of propofol/dexmedetomidine versus desflurane for maintenance of general anesthesia on hepatocellular injury in patients undergoing partial hepatectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients American Society of Anesthesiologists physical status (ASA) I to II.
- •Patients Child Pugh classification A to B.
- •Both sexes.
- •Aged between 18 years and 70 years
- •Scheduled for more than 1 segment hepatectomy.
排除标准
- •Patients with Child Pugh classification C.
- •Patients younger than18 years old or older than 70 years old
- •Patients performed additional ablation therapies (cryosurgery or radiofrequency ablation).
- •Prior liver resection for donation.
- •Scheduled resection not requiring inflow occlusion (Pringle's maneuver).
- •Hypersensitivity to any of the used drugs.
研究组 & 干预措施
propofol and dexmedetomidine
Patients will receive maintenance of general anesthesia by TIVA using combination of propofol and dexmedetomidine
干预措施: Propofol, dexmedetomidine (Drug)
desflurane
Patients will receive maintenance of general anesthesia by desflurane.
干预措施: Desflurane (Drug)
结局指标
主要结局
bilirubin
时间窗: 1 week
bilirubin
albumin
时间窗: 1 week
albumin
aspartate aminotransferase (AST)
时间窗: 1 week
aspartate aminotransferase (AST)
alanine aminotransferase (ALT)
时间窗: 1 week
alanine aminotransferase (ALT)
prothrombin time
时间窗: 1 week
prothrombin time
INR
时间窗: 1 week
INR
次要结局
未报告次要终点