Propofol/Dexmedetomidine Versus Desflurane Effects on Post Hepatectomy Hepatocellular Injury
Trial Snapshot
- Phase
- Early Phase 1
- Status
- Recruiting
- Sponsor
- Ain Shams University
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- bilirubin
Study Overview
Brief Summary
This study will compare the effects of propofol/dexmedetomidine versus desflurane for maintenance of general anesthesia on hepatocellular injury in patients undergoing partial hepatectomy.
Detailed Description
Postoperative impairment of liver function is common after hepatectomy. It may be caused by surgical trauma, loss of hepatic mass, stress response, hepatic oxygen deprivation, infection and drug toxicity.
Anesthetic agents used in general anesthesia for liver surgery have a big effect on hepatic blood flow, oxygen delivery and liver function This study will compare the effects of propofol/dexmedetomidine versus desflurane for maintenance of general anesthesia on hepatocellular injury in patients undergoing partial hepatectomy.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 70 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients American Society of Anesthesiologists physical status (ASA) I to II.
- •Patients Child Pugh classification A to B.
- •Both sexes.
- •Aged between 18 years and 70 years
- •Scheduled for more than 1 segment hepatectomy.
Exclusion Criteria
- •Patients with Child Pugh classification C.
- •Patients younger than18 years old or older than 70 years old
- •Patients performed additional ablation therapies (cryosurgery or radiofrequency ablation).
- •Prior liver resection for donation.
- •Scheduled resection not requiring inflow occlusion (Pringle's maneuver).
- •Hypersensitivity to any of the used drugs.
Arms & Interventions
propofol and dexmedetomidine
Patients will receive maintenance of general anesthesia by TIVA using combination of propofol and dexmedetomidine
Intervention: Propofol, dexmedetomidine (Drug)
desflurane
Patients will receive maintenance of general anesthesia by desflurane.
Intervention: Desflurane (Drug)
Outcomes
Primary Outcomes
bilirubin
Time Frame: 1 week
bilirubin
albumin
Time Frame: 1 week
albumin
aspartate aminotransferase (AST)
Time Frame: 1 week
aspartate aminotransferase (AST)
alanine aminotransferase (ALT)
Time Frame: 1 week
alanine aminotransferase (ALT)
prothrombin time
Time Frame: 1 week
prothrombin time
INR
Time Frame: 1 week
INR
Secondary Outcomes
No secondary outcomes reported