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临床试验/NCT02142439
NCT02142439已完成不适用

Strength Training and Eating Disorders (STERK - Styrketrening og Spiseforstyrrelser)

University of South-Eastern Norway4 个研究点 分布在 1 个国家目标入组 6 人开始时间: 2014年1月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
6
试验地点
4
主要终点
Bone mineral density (DXA)

研究概览

简要总结

Strength training has been found effective for enhancement of bone health, muscle strength and body composition among premenopausal women from the general population, however it is unclear to what extend strength training might improve these parameters among women with eating disorders. The aim of this study is therefore to examine acute and long-term effects of strength training among persons with eating disorders. The study is a randomized, controlled, single-blinded trial with three intervention groups and one control group. The three intervention groups will perform different volumes of strength training. The intervention period is 16 weeks with three sessions per week. At pretest, posttest, and 6 months, 12 months and 24 months follow-up, the following variables will be measured: bone health, muscle strength, power, body composition hormone levels, physical activity level and compulsivity, body awareness, quality of life, and eating disorders psychopathology. Qualitative in-depth interviews will be carried out to explore the participants' experiences with strength training. The study is carried out in Norway, and is performed in collaboration with Telemark University College, University of Agder, Norwegian school of sport sciences and Modum Bad psychiatric center. The results from the study might implicate on strength training as part of treatment for eating disorders.

详细描述

ED are mental disorders which often lead to serious medical complications such as hormone disturbances, osteopenia/osteoporosis, and myopathy. More than 90% of females with anorexia nervosa (AN) have osteopenia, and almost 40% have osteoporosis. Osteoporosis in the European Union is estimated to cost 37 billion euros each year, and the majority of persons with osteoporosis are untreated. Although economic analysis of osteoporosis in Norway is lacking, the prevalence of osteoporosis in Norway is among the world's highest.

Strength training is effective in treatment of osteoporosis among postmenopausal women. Despite this, evidence based knowledge about strength training as a possible treatment-option for osteopenia/osteoporosis in ED is lacking. Due to the long half-life of bisphosphonates, such medications must be used carefully among young adults. Hence, there are no current well-documented treatment strategies for osteopenia/osteoporosis for this age group.

Although excessive physical activity is a common symptom among persons with ED, strength training is an exercise modality rarely used in this population. In addition, restoration of body weight is an important treatment goal for underweight persons with ED. Such a weight restoration leads to altered body composition with higher increase in adipose tissue compared to lean tissue, and the adipose tissue often redistribute to more abdominal fat. Such altered body composition might increase risk of cardiovascular disease and increased body dissatisfaction, and hence increase risk of relapse.

Strength training affects body composition in persons both with and without ED. It is therefore interesting to examine if strength training intervention affects body dissatisfaction, and hence reduce psychopathology and increase quality of life, among persons suffering from ED.

Existing studies with strength training intervention use different repetitions, sets and intensities. Campos et al. found that few repetitions (i.e. 3-5 rep x 3 sets) were more effective in increasing muscle strength compared to medium (9-11 rep x 3) and many repetitions (20-28 rep x 2), while the latter gave largest increase in muscular endurance among healthy males. Mosti et al. found increased bone mass in lumbar spine and femur neck and alterations in blood bone markers after 12 weeks of strength training (3-5 reps x 4 sets, 85-90% of 1RM) among postmenopausal women with osteopenia/osteoporosis. A study using both low and high intensity strength training intervention lasting for 12 months found increased bone mineral density (BMD) in lumbar spine among healthy elderly women. The few existing studies using strength training among persons with ED have all used low intensity strength training, and none of these have examined the effects on bone health. Two randomized controlled trials found effect of strength training on body composition, muscle strength and quality of life among persons with Anorexia Nervosa, whereas Del Valle et al. only found effects on quality of life. The low intensity might explain the lack of effects in the latter study. It is therefore a need for studies using adequate dosage of strength training among persons with ED.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Single (Investigator)

入排标准

年龄范围
18 Years 至 60 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Meeting diagnostic criteria for anorexia nervosa, bulimia nervosa or eating disorders not otherwise specified
  • Outpatient/home-dwelling
  • Age: 18 years or older
  • Premenopausal women

排除标准

  • BMI <15 kg/m2
  • Osteoporosis (t-score < -2,5 including low energy fracture)
  • Psychosis, suicidal behavior
  • Planned changes in medication during the 16 weeks of intervention
  • Planned pregnancy within the 16 weeks intervention period, and/or up to one year follow-up (due to DXA scanning)

结局指标

主要结局

Bone mineral density (DXA)

时间窗: up to two years follow-up

次要结局

  • 1RM squats(16 weeks, two years follow-up)
  • Self-reported physical activity behavior(16 weeks, two years follow-up)
  • symptom check list (SCL-90)(16 weeks, two years follow-up)
  • blood levels(16 weeks, two years follow-up)
  • DXA(16 weeks, two years follow-up)
  • Hormone levels(16 weeks, two years follow-up)
  • 1RM bench press(16 weeks, two years follow-up)
  • Eating Disorders Examination clinical interview(16 weeks, two years follow-up)

研究者

发起方
University of South-Eastern Norway
申办方类型
Other
责任方
Sponsor

研究点 (4)

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