A Retrospective Cohort Study: Influence of MTHFR C677T and A1298C Polymorphisms on the Survival of Pediatric Patients With Non-Hodgkin's Lymphoma

Completed

• Conditions: Pediatric Non-Hodgkin Lymphoma

• Registration Number: NCT04469543
• Lead Sponsor: Sun Yat-sen University

Brief Summary

The primary purpose of this retrospective study was to investigate the influence of methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphism on the survival of pediatric patients with Non-Hodgkin lymphoma (NHL) treated with modified NHL-BFM95 protocol in south China.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-01-20
• Primary Completion: 2020-02-06
• Study Completion: 2020-05-20
• Status Verified: 2020-07
• Study First Submitted: 2020-07-09
• Study First Submitted QC: 2020-07-09
• Last Update Submitted: 2020-07-09
• Study First Posted: 2020-07-14
• Last Update Posted: 2020-07-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 374

Inclusion Criteria

1. aged ≤ 18 years;
2. newly diagnosed as the four main categories of NHL(Burkitt's lymphoma, lymphoblastic lymphoma, anaplastic large cell lymphoma, and diffuse large B-cell lymphoma) between 2014 and 2020;
3. treated according to the modified BFM95 protocol.

Exclusion Criteria

1. aged > 18 years;
2. not newly diagnosed as the four main categories of NHL between 2014 and 2020;
3. treated according to chemotherapeutic regimens except for the modified BFM95 protocol.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Death	About six years	Overall survival time was calculated from the time of initial diagnosis to death
Events including progression, relapse, and secondary cancer	About six years	Event-free survival (EFS) time was calculated from the time of initial diagnosis to first event.

Trial Locations

Locations (1)

Sun Yat-Sen University Cancer Center; 🇨🇳 Guangzhou, Guangdong, China