The Efficacy of Dexamethasone Versus Magnesium Sulphate Added to Bupivacaine Used in Erector Spinae Plane Block for Perioperative Pain Control in Patients Undergoing Unilateral Nephrectomy
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 78
- 试验地点
- 1
- 主要终点
- postoperative opioid consumption
研究概览
简要总结
Aim of the study:
The current study aims to compare the effect of adding dexamethasone versus magnesium sulfate to bupivacaine in ultrasound-guided erector spinae plane block on the severity of postoperative pain.
Primary Objectives:
- To compare the effect of ESPB without additives to the effect of adding dexamethasone and to the impact of adding magnesium sulfate in the form of post-operative morphine consumption
详细描述
Aim of the study:
The current study aims to compare the effect of adding dexamethasone versus magnesium sulfate to bupivacaine in ultrasound-guided erector spinae plane block on the severity of postoperative pain and postoperative morphine consumption.
Methodology:
I. Study design:
This is a randomized Controlled Study. It will involve three groups: Control Group (C) receiving erector spinae block with 27ml bupivacaine 0.25% + 3 ml NS, Group (M) receiving 27 ml bupivacaine 0.25% + 3 ml magnesium sulphate 10%, Group (D) receiving 27 ml bupivacaine 0.25% + 8 mg dexamethasone (2 ml) + 1 ml NS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult (18 - 65)
- •Patients undergoing unilateral nephrectomy
- •ASA II / III
排除标准
- •Patient refusal
- •Age less than 18 years
- •Allergy to any of the studied medications
- •Mid line incision
- •Bilateral nephrectomy
- •Distorted anatomy of the back (e.g. kyphoscoliosis)
- •Known neurologic disorders, psychiatric disorder or chronic pain
- •Local infection
- •Hemodynamic instability
结局指标
主要结局
postoperative opioid consumption
时间窗: 24 hours post-operatively
total postoperative rescue analgesia be by Morphine
次要结局
- time of first rescue analgesia(during 1st 24 postoperatively.)
- Intraoperative opioid consumption(intraoperative)
- visual analogue scale 30 hours post-operatively at rest(24 hours post-operatively at rest)
研究者
Ahmed Mohamed Soliman
lecturer of anesthesia
National Cancer Institute, Egypt