EUCTR2014-003731-20-ES进行中（未招募）1 期
A phase II, multicenter, open-label study of EGF816 in combination with Nivolumab in adult patients with EGFR mutated non-small cell lung cancer and of INC280 in combination with Nivolumab in adult patients with cMet positive non-small cell lung cancer
ovartis Farmacéutica, S.A.0 个研究点目标入组 100 人开始时间: 2015年1月9日最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 100
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •? Advanced metastatic and/or unresectable NSCLC
- •? Measurable disease as determined by RECIST version 1.1
- •? ECOG performance ?2
- •? Patients in Group 1: confirmed T790M EGFR mutation
- •? Patients in Group 2: confirmed c-MET positive
- •Other inclusion criteria may apply as per protocol
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range 50
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range 50
排除标准
- •? For Group 1: Patients who have received more than one prior line of EGFR TKI therapy
- •? For Group 2: Previous treatment with a c-MET inhibitor or HGF-targeting therapy
- •? Prior treatment with PD1/PD-L1 targeting therapies
- •? Subjects who require emergent use of systemic steroids, emergent surgery and/or radiotherapy
- •? Patients with interstitial lung disease
- •? Patients with any active or history of autoimmune disease
- •Other exclusion criteria may apply as per protocol
研究者
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