Transpulmonary Gradient of Inflammation Biomarkers and Pulmonary Vascular Resistance in Acute Respiratory Failure After Cardiac Surgery Under Cardiopulmonary Bypass
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- transpulmonary gradients of inflammation biomarkers (sRAGE, sICAM-1, SPB, PAI-1, ROS) and pulmonary vascular resistance
研究概览
简要总结
Get a better understanding of the pathophysiological processes of acute respiratory failure following cardiopulmonary bypass to initiate timely therapies targeted on a cell line.
Demonstrate that there is a relationship between increased transpulmonary gradients of inflammation biomarkers (sRAGE, sICAM-1, SPB, PAI-1, ROS) and pulmonary vascular resistance on the one hand and alveolo-capillary gas exchange on the other hand after cardiac surgery under cardiopulmonary bypass.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient man or woman > 18 y.o.
- •Patient has signed informed consent prior to the study
- •Patient affiliated to a social security administration
- •Patient operated on for cardiac surgery at the University Hospital of Strasbourg.
- •Patient at high risk for postoperative respiratory failure defined by a SLIP score (Kor et al.) ≥ 22 Kor:
- •High-risk cardiac intervention under cardiopulmonary bypass (19 pts)
- •COPD (10 pts)
- •Diabetes (6 pts)
- •gastroesophageal reflux (7 pts)
- •Alcohol abuse (11 pts)
- •Scheduled use of a pulmonary artery catheter and a left atrial catheter
排除标准
- •Inability to obtain informed consent from the patient and / or unable to give informed patient information (difficulty understanding ...)
- •Urgent surgery (<24h)
- •Acute heart failure
- •Patient ventilated preoperatively
- •Allergy to Latex
- •Persons deprived of liberty or under judicial protection
- •Patient placed under guardianship
- •Pregnancy
- •Breastfeeding
结局指标
主要结局
transpulmonary gradients of inflammation biomarkers (sRAGE, sICAM-1, SPB, PAI-1, ROS) and pulmonary vascular resistance
时间窗: during the surgery
Demonstrate that there is a relationship between increased transpulmonary gradients of inflammation biomarkers (sRAGE, sICAM-1, SPB, PAI-1, ROS) and pulmonary vascular resistance on the one hand and alveolo-capillary gas exchange on the other hand after cardiac surgery under cardiopulmonary bypass.
次要结局
未报告次要终点