Advancing Varenicline as a Treatment for Cannabis Use Disorder
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 72
- 试验地点
- 1
- 主要终点
- Cannabis Withdrawal Symptoms During Active Treatment
研究概览
简要总结
Marijuana is the most commonly used illicit drug. There is high demand for effective interventions for cannabis use disorder, yet few specific treatments for have been developed. This study will evaluate the efficacy of varenicline for reducing marijuana use in people who use marijuana frequently.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Varenicline
2 mg daily
干预措施: Varenicline (Drug)
Placebo
2 mg daily
干预措施: Placebo (Drug)
结局指标
主要结局
Cannabis Withdrawal Symptoms During Active Treatment
时间窗: 3 weeks (Week 4-6 of active treatment period)
For this outcome, the negative affect subscale items of The Cannabis Withdrawal Scale (items 5 \["I felt nervous\], 6 \["I had some angry outbursts"\], 7 \["I had mood swings"\], 8 \["I felt depressed"\], 9 \["I was easily irritated"\], 15 \["Life seemed an uphill struggle"\], 18 \["I felt physically tense"\], restlessness (item 11, "I felt restless), and/or urge to smoke (items 1 and 10, "The only thing I could think about was smoking some cannabis" and "I had been imagining being stoned") were averaged at Weeks 4, 5, and 6 and for an overall 4-6 week value, with minimum score of the subscale being 0 and maximum score being 100 (higher score indicating worse outcome).
次要结局
- Number of Participants With Cannabis Abstinence(3 weeks (Week 4-6 of active treatment period))
- Cannabis Use Quantity(3 weeks (Week 4-6 of active treatment period))
研究者
Aimee McRae-Clark
Professor of Psychiatry
Medical University of South Carolina