One-lung Ventilation: Expression of Pulmonary Inflammatory Mediators
Not Applicable
Completed
- Conditions
- Thoracic Surgery With One-lung Ventilation
- Registration Number
- NCT00515905
- Lead Sponsor
- University of Zurich
- Brief Summary
One-lung ventilation; organ protection; volatile anesthetics
One-lung ventilation has become a common procedure for thoracoscopic surgery. Two hypothesis will be tested in this study:
1. Are inflammatory mediators increased in the re-ventilated lung after short-period pulmonary collapse?
2. Does Sevoflurane influence the production of inflammatory mediators in the re-inflated lung? Therefore, this study will elucidate the potential protective effect of a volatile anaesthetic (sevoflurane) on the production of inflammatory mediators by the respiratory compartment of the lung, i.e. the alveolar epithelium.
* Trial with immunomodulatory product / biological
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 76
Inclusion Criteria
Not provided
Exclusion Criteria
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method One-lung ventilation measurement in the re-ventilated lung after short-period pulmonary collapse Sep 07
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University Hospital of Zurich
🇨🇭Zurich, Switzerland