Comparison of extracorporeal liver support systems MARS and SPAD in a cross over desig
Phase 4
- Conditions
- Acute and acut-on-chronic liver failureK70K77T86.4K71K72K73K74K75K76
- Registration Number
- DRKS00000371
- Lead Sponsor
- Klinik für Anästhesiologie und IntensivtherapieUniversitätsklinikum Jena
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 32
Inclusion Criteria
acute or acute-on-chronic liver failure
- Serum bilirubin > 8-10 mg/dl ( 136-171 µmol/l) und plasma disappearance rate of indocyanine green (PDRICG) < 8-10 %
Exclusion Criteria
Age below 18 years
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes of serum bilirubin concentrations, blood samples before and after albumin dialysis
- Secondary Outcome Measures
Name Time Method Changes of other laboratory parameters before and after each cycle of albumin dialysis:<br>blood samples for laboratory parameters (albumin binding capacity, bile acids, indols, phenols, ammonia, Liver parameters (ASAT, ALAT, GLDH, GGT, AP), albumin, total proteins, lactate, creatinine, urea, blood count (hb, hct, WBC, thrombocytes), coagulation parameters (prothrombin ratio, PTT, factor V, fibrinogen, antithrombin), electrolytes (sodium, potassium, calcium), cytokines, vasoactive substances, etc.) || classification of hepatic encephalopathy grade before and after each cycle of albumin dialysis (HE-grade; in awake patients additionaly determination with:Hepatic Encephalopathy Scoring Algorithm) || organ dysfunction before and after each cycle of albumin dialysis (SOFA-Score, catecholamine dose, cardiac output (assessment with PiCCO) || plasma disappearance rate of indocyanine green (PDR-ICG; assessment with LiMON) before and after each cycle of albumin dialysis