of-1 trials of stimulants versus placebo and each other for Attention Deficit Hyperactivity Disorder in childre
- Conditions
- Attention Deficit Hyperactivity DisorderMental and Behavioural DisordersBehavioural and emotional disorders with onset usually occurring in childhood and adolescence
- Registration Number
- ISRCTN24045888
- Lead Sponsor
- The University of Queensland (Australia)
- Brief Summary
2006 results in: https://www.ncbi.nlm.nih.gov/pubmed/16740846 (added 21/05/2019)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 86
1. Any school age patient with a clinical diagnosis of ADHD of at least a month's duration, in the opinion of the attending medical practitioner, who is stabilised on treatment with Ritalin
2. Patient, parent and doctor would like to use the n-of-1 trial methodology to see if the patient is a responder to methylphenidate or dexamphetamine
1. Advanced arteriosclerosis
2. Symptomatic cardiovascular disease
3. Moderate to severe hypertension
4. Hyperthyroidism
5. Phaeochromocytoma
6. Glaucoma
7. Agitated states
8. Anxiety
9. Motor tics
10. Tourette syndrome
11. Monoamine Oxidase Inhibitors (MAOIs) (+/- 14 days)
12. Idiosyncratic reaction to sympathomimetic amines
13. History of drug abuse
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br> 1. Conners' Teacher and Parent self reported revised short form<br> 2. Conners-Wells Adolescent Rating Scales<br><br> Outcomes will be measured at baseline and at the end of each treatment period.<br>
- Secondary Outcome Measures
Name Time Method o secondary outcome measures