A COMPARATIVE STUDY OF EFFICACY OF ORAL TRANEXAMIC ACID AND ITS COMBINATION WITH Nd-YAG LASER IN MELASMA.

Not Applicable

Completed

• Conditions: Health Condition 1: L814- Other melanin hyperpigmentation

• Registration Number: CTRI/2021/01/030539
• Lead Sponsor: Dr Abdul Sahid Khan

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2022-02-10
• Last Update Posted: 17 October 2022

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

All the patients with melasma of age 18years to 50years attending SKIN & VD OPD in between the study period

Exclusion Criteria

1.Patients with history of coagulopathies, cardiac diseases and severe systemic disorders.

2.Use of oral anticoagulant drugs or any other photosensitizing drugs such as NSAID, tetracycline, spironolactone, phenytoin, carbamazepine in last 1 month.

3.Known allergy to Tranexamic acid.

4.Use of other depigmenting oral or topical agents in the past 1 month.

5.Females with a history of pregnancy/lactation in last 12 months.

6.Use of oral contraceptive pills/hormonal replacement therapy in the past 12 months.

7.Patients with unusually high expectations.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The combination of Oral Tranexamic acid and Qs Nd-YAG laser is expected to be better with minimum 60% decrease in MASI score where as only Oral Tranexamic acid is expected to have a reduction in MASI by 40-45%. <br/ ><br>Timepoint: the patients will be evaluated after 6months of the beginning of treatment to see for the change in masi scores. <br/ ><br>

Secondary Outcome Measures

Name	Time	Method
To see the efficacy of Oral Tranexamic acid in Melasma. <br/ ><br>To see the efficacy of Oral Tranexamic acid and Q Switched Nd-YAG laser in Melasma. <br/ ><br>To see if Oral Tranexamic acid decreases the side effects of Q Switched Nd-YAG lasers in comparison to other studies. <br/ ><br>To compare the efficacy of oral Tranexamic acid with Q switched Nd YAG laser against Oral Tranexamic acid alone in cases of Melasma. <br/ ><br>Timepoint: patients will be evaluated at monthly interval , and before and after each laser session to see for improvement and side effects.