A Single-centre, Open-label, Randomised, Cross-over, Drug-drug Interaction Study to Investigate the Effect of Repeated Oral Doses of Ciclosporin on the Single-dose Pharmacokinetics of nASP2151 in Healthy Mean

Maruho Europe Limited1 个研究点分布在 1 个国家目标入组 26 人开始时间: 2014年10月最近更新: 2019年5月3日

适应症

干预措施

试验速览

阶段: 1 期
状态: 已完成
发起方
入组人数: 26
试验地点: 1
主要终点: Time of Peak Concentration (Tmax) of ASP2151

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

ASP2151 is an experimental treatment for herpes. Patients undergoing organ and tissue transplantation may be prescribed ciclosporin to suppress their immune system to give the transplant an increased chance of not being rejected. A patient with a compromised immune system is more susceptible to infections such as herpes, which will require treatment.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Crossover
主要目的: Other
盲法: None

入排标准

年龄范围: 18 Years 至 45 Years（Adult）
性别: Male
接受健康志愿者: 是

入选标准

•A body mass index (Quetelet index) in the range 18.0-30.9 kg/m
•Sufficient intelligence to understand the nature of the trial and any hazards of participating in it. Ability to communicate satisfactorily with the investigator and to participate in, and comply with the requirements of, the entire trial.
•Willingness to give written consent to participate after reading the information and consent form, and after having the opportunity to discuss the trial with the investigator or his delegate.
•Willingness to give written consent to have data entered into The Overvolunteering Prevention System (TOPS).

排除标准

•Clinically relevant abnormal history, physical findings, ECG, or laboratory values at the pre-trial screening assessment that could interfere with the objectives of the trial or the safety of the volunteer.
•Any of the following liver function tests higher than 1.5 times the ULN at the screening visit: aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), bilirubin, gamma glutamyl transpeptidase (gamma-GT).
•Platelet counts outside normal limits.
•Presence of acute or chronic illness or history of chronic illness sufficient to invalidate the volunteer's participation in the trial or make it unnecessarily hazardous.
•Clinically significant impaired endocrine, thyroid, hepatic, respiratory or renal function, diabetes mellitus, coronary heart disease, or history of any psychotic mental illness.
•Receipt of a live vaccine in the 3 months before the first dose of study medication, or planned immunisation with a live vaccine during the study.
•Evidence of any significant bacterial, viral, fungal or parasitic infection during the 4 weeks before dosing (minor fungal nail infections will not be regarded as significant); minor infection (eg common cold) not requiring anti-infective treatment during the 2 weeks before dosing.
•History of bleeding diathesis.
•Surgery (eg stomach bypass) or medical condition that might affect absorption of medicines.
•Presence or history of severe adverse reaction to any drug, history of multiple drug allergies (multiple defined as >3), or sensitivity to trial medication.
•Use, during the 28 days before the first dose of trial medication, of any prescription medicine, or any other medicine or herbal remedy (such as St John's wort) known to interfere with the CYP3A4 metabolic pathway (unless judged as not clinical significant by the investigator and sponsor). See Appendix 1 for common CYP3A4 interactors/substrates.
•Use, during the 7 days before the first dose of trial medication, of any over-the-counter medicine, with the exception of paracetamol (acetaminophen).
•Participation in another clinical trial of a new chemical entity or a prescription medicine within the previous 3 months.
•Loss of more than 400 mL blood during the 3 months before the trial, eg as a blood donor.
•Presence or history of drug or alcohol abuse, or intake of more than 21 units of alcohol weekly or more than 5 cigarettes daily.
•Evidence of drug abuse on urine testing.
•Positive test for hepatitis B antigen (HBsAg); or positive test for hepatitis B core antibody (HBcAb).
•Positive test for hepatitis C, HIV1, HIV2, or active and latent tuberculosis.
•Blood pressure and heart rate in seated position at the screening examination outside the ranges 90-140 mm Hg systolic, 40-90 mm Hg diastolic; heart rate 40-100 beats/min.
•Possibility that the volunteer will not cooperate with the requirements of the protocol.
•Objection by General Practitioner (GP) to volunteer entering trial.

研究组 & 干预措施

ASP2151 400mg

Other

ASP2151 400mg + 100mg ciclosporin

干预措施: ASP2151 400mg + 100mg ciclosporin (Drug)

ASP2151 1200mg

Other

ASP2151 1200mg + 100mg ciclosporin

干预措施: ASP2151 1200mg + 100mg ciclosporin (Drug)