Effect of Panax Ginseng C.A. Mey Extract on Liver Function in Adults

Not Applicable

Recruiting

• Conditions: Liver Diseases
• Interventions: Dietary Supplement: Placebo group; Dietary Supplement: Panax Ginseng C.A. Mey Extract group

• Registration Number: NCT03775837
• Lead Sponsor: Pusan National University Yangsan Hospital

Brief Summary

The investigators conduct a randomized, double-blind, placebo-controlled study to investigate the effects of Panax Ginseng C.A. Mey Extract on liver function in adults for 8 weeks.

Detailed Description

Previous studies have indicated that Panax Ginseng C.A. Mey Extract may have the ability to improve liver function. Therefore, the investigators conduct a randomized, double-blind, placebo-controlled study to investigate the effects of the Panax Ginseng C.A. Mey Extract on liver function in adults; the safety of the compound are also evaluate. The Investigators examine AST, ALT, GGT, and other metabolic parameters at baseline, as well as after 4 and 8 weeks of intervention. Sixty adults were administered either 600 mg of Panax Ginseng C.A. Mey Extract or a placebo each day for 8 weeks;

Study Timeline

• Study Start: 2018-12-01
• Study First Submitted: 2018-12-11
• Study First Submitted QC: 2018-12-11
• Study First Posted: 2018-12-14
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-07
• Last Update Posted: 2024-04-09
• Primary Completion: 2024-12-30
• Study Completion: 2024-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• ALT ranging from upper limit of reference to three times of upper limit

Exclusion Criteria

• Abnormal liver or renal function (i.e., serum aminotransferase activity > 3 times of upper limit of reference range and serum creatinine concentrations > 1.2 mg/dL)
• Diabetes (diagnosed clinically or fasting glucose level > 126 mg/dL)
• History of viral hepatitis or cancer
• Uncontrolled hypertension
• History of serious cardiac disease such as angina or myocardial infarction
• History of gastrectomy
• History of medication for psychiatric disease
• Administration of oriental medicine including herbs within the past 4 weeks

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo group	Placebo group	This group takes placebo for 8 weeks
Panax Ginseng C.A. Mey Extract group	Panax Ginseng C.A. Mey Extract group	This group takes Panax Ginseng C.A. Mey Extract for 8 weeks

Primary Outcome Measures

Name	Time	Method
Alanine aminotransferase	8 weeks	Alanine aminotransferase

Secondary Outcome Measures

Name	Time	Method
Aspartate aminotransferase	8 weeks	Aspartate aminotransferase
Gamma-glutamyl transferase	8 weeks	Gamma-glutamyl transferase

Trial Locations

Locations (1)

Integrated Research Institute for Natural Ingredients and Functional Foods; 🇰🇷 Yangsan, Korea, Republic of