Genetic Predictors of Renal Dysfunction Following Heart Transplantation

Active, not recruiting

• Conditions: Heart Transplantation; Chronic Renal Insufficiency

• Registration Number: NCT01686191
• Lead Sponsor: University of Colorado, Denver

Brief Summary

Kidney disease is a common problem after heart transplantation. It may be caused by anti-rejection medications such as cyclosporine or tacrolimus. However, the reason why some people develop kidney problems after a heart transplant, but other people do not, is not fully known. This study plans to learn more about the relationship between a person's genetic make-up (DNA; deoxyribonucleic acid) and the risk of kidney problems after a heart transplant. The long-term goal of this research is to identify genetic variations that may help predict the development of kidney problems after heart transplantation.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-08
• Study First Submitted: 2012-09-12
• Study First Submitted QC: 2012-09-14
• Study First Posted: 2012-09-17
• Status Verified: 2023-05
• Last Update Submitted: 2023-05-09
• Last Update Posted: 2023-05-10
• Primary Completion: 2025-12
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• cardiac-only transplant
• 18 years of age or older at the time of cardiac transplant
• 1 year or more post-cardiac transplant
• treatment with cyclosporine or tacrolimus following transplant

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Exclusion Criteria

• combined organ transplant
• decisionally impaired
• unable to read or speak English
• unable or unwilling to provide written informed consent

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Chronic renal dysfunction	year 2 post-transplant

Trial Locations

Locations (1)

University of Colorado Anschutz Medical Campus; 🇺🇸 Aurora, Colorado, United States