Impact of Endogenous Sexual Hormones (Oestrogens and Testosterone) on the Endothelium Circulatory on Rolling at the Young and Old Healthy Volunteer.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- Number of endothelial progenitor cells by cytometry
研究概览
简要总结
The purpose of this study is to determine whether the number of circulating EPC is different between healthy women and men.
详细描述
Study design: Open pilot study in health volunteers in the Hospital Saint-ANTOINE's Clinical Investigation Centre (CIC).
Recruitment and course of the study: The subjects will be recruited among the CIC's pool of healthy volunteers. Volunteer people will then have biological and clinical baseline examinations. If they match the inclusion criteria, an appointment will be taken for the blood sample intend for the characterization of the EPC and hormonal plasma levels evaluation. The participation will not exceed 2 months. Young women will have to come between the 9th and the 11th day after the beginning of menses). A total of 150 ml of peripheral blood will be collected. The study will last 18 months.
研究设计
- 研究类型
- Observational
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 79 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI between 19 and 25 kg/m²
- •non menopausal women :
- •age 18 to 40 years,
- •regular menstrual cycles
- •no hormone therapy as contraceptives
- •postmenopausal women :
- •age above 55 years old
- •amenorrhoea since 5 years at least
- •no hormone therapy since at least 3 month
排除标准
- •no medical insurance
- •inclusion in another study
- •smoking, Statins treatment, uncontrolled diabetes or hypertension and personal history of cardiovascular disease.
结局指标
主要结局
Number of endothelial progenitor cells by cytometry
时间窗: Baseline
次要结局
- To compare the number of EPC in young women to older men and menopausal women. To evaluate the correlation between the number of EPC and 17 b-estradiol plasma level.(Baseline)