2025-520637-24-00招募中2 期
Use of a new diagnostic tool in the detection and characterization of endometriosis lesions. ENDO-TEP
适应症
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Characterization of the hypermetabolism of lesions on PET by analysis of SUV: Hypermetabolism present or not and quantification
研究概览
简要总结
The main objective is to study the use of a new diagnostic tool: [18F]-FES PET/CT in the detection and characterisation of endometriosis lesions in association with pain.
入排标准
- 年龄范围
- 18 years 至 64 years（18-64 Years）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Test: Painful patients with VAS ≥ 4 treated surgically for painful symptoms related to endometriosis
- •Control: Patient with VAS < 4 treated surgically for endometriosis in the context of infertility
- •Age > 18 years old
- •Patient with informed consent
- •Patients with preoperative MRI not contraindicated for [18F]-FES PET/CT
- •Patient operated on mid-cycle
- •Membership of a Social Security scheme
排除标准
- •Patient treated for endometriosis without surgery
- •Pregnant patient
- •Claustrophobic patient
- •Hypersensitivity to the active substance (Fluoroestradiol(18F)) or to one of the excipients
- •Patient under legal protection
- •Patient taking hormonal treatment
- •Menopausal patient
结局指标
主要结局
Characterization of the hypermetabolism of lesions on PET by analysis of SUV: Hypermetabolism present or not and quantification
Characterization of the hypermetabolism of lesions on PET by analysis of SUV: Hypermetabolism present or not and quantification
次要结局
- Analyzes of lesions in Immunohistochemistry (IHC) and results of in situ hybridization: Characterization of the markings (intensity, type of receptor expressed, etc.) for each lesion depending on the anatomical location.
- Analyzes of lesions in Immunohistochemistry and results of in situ hybridization: Characterization of the markings (intensity, type of receptor expressed, etc.) for each patient according to pain (VAS)
- Sensitivity of [18F]-FES PET/CT compared to that of MRI in the diagnosis of superficial and deep endometriosis lesions and according to their location
- Degree of association between [18F] SUV intensity and ER expression (IHC) and pain intensity (VAS)
研究者
Ariane WEYL
Scientific
Centre Hospitalier Universitaire De Toulouse
研究点 (1)
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