Evaluation of the effectiveness of probiotic/prebiotic on the severity of depressive symptoms and irritable bowel syndrome
- Conditions
- Irritable bowel syndrome.Irritable bowel syndrome
- Registration Number
- IRCT20190404043159N5
- Lead Sponsor
- Esfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 48
Age 18 to 65 years
Diagnosis of moderate to severe IBS based on ROME III criteria
Have a minimum literacy
Absence of Depressive Disorders, Bipolar Disorders or Psychotic Disorders Based on DSM-V Diagnostic Criteria by Psychiatrist and Psychiatric Assistant
No suicidal plans or thoughts at the time of enrollment
Do not take antidepressants and anti-anxiety drugs at the time of enrollment until 2 weeks before
No pregnancy or breastfeeding
No history of any bowel surgery
Do not use drugs since the onset of symptoms
Satisfaction to participate in the study
Diagnosis of any organic disease during the study
Lack of cooperation in taking medications regularly
Causes any side effects, including allergic and gastrointestinal side effects
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Symptoms of Irritable Bowel Syndrome. Timepoint: Before intervention, 6 and 12 weeks after intervention. Method of measurement: Questionnaire the irritable bowel severity scoring system (IBSSS).
- Secondary Outcome Measures
Name Time Method Depression. Timepoint: Before intervention, 6 and 12 weeks after intervention. Method of measurement: Questionnaire of Depression, Anxiety and Stress Scale (DASS).;Anxiety. Timepoint: Before intervention, 6 and 12 weeks after intervention. Method of measurement: Questionnaire of Depression, Anxiety and Stress Scale (DASS).;Stress. Timepoint: Before intervention, 6 and 12 weeks after intervention. Method of measurement: Questionnaire of Depression, Anxiety and Stress Scale (DASS).