Concomitant intraventricular fibrinolysis and low-frequency rotation after severe subarachnoid hemorrhage

Phase 2

Completed

• Conditions: Aneurysmal subarchnoid hemorrhage; Circulatory System; Subarachnoid haemorrhage

• Registration Number: ISRCTN13230264
• Lead Sponsor: Heinrich-Heine University (Germany)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-09-03
• Last Update Posted: 3 July 2017

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Aneurysmal SAH (WFNS grade III-V)
2. Fisher grade II - IV
3. Patient age > 18
4. Admission less than 24 hours after ictus
5. No history for anticoagulative or antiaggregative agents
6. Informed consent by a legal representative

Exclusion Criteria

1. Non-aneurysmal or Fisher ° 0-I SAH
2. Fusiform, mycotic or traumatic aneurysms
3. Pregnancy
4. Admission greater than 24 hours after ictus
5. History for severe cardiovascular disease
6. Clotting disorders
7. Platelet count less than 100,000, INR greater than 1.4
8. Ongoing internal bleeding

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Glasgow outcome score at discharge and after 6 weeks

Secondary Outcome Measures

Name	Time	Method
1. Clot clearance rate (CCR) between day 1 and day 5 after SAH ictus<br>2. Radiographic vasospasm between day 1 and day 15 after SAH ictus<br>3. New cerebral infarction on discharge CT or after death <br>4. Occurrence of posthemorrhagic hydrocephalus at discharge