Comparison of the Effect of A-PRF and L-PRF on Outcomes After Removal of Impacted Mandibular Third Molar

Not Applicable

Completed

• Conditions: Pain, Postoperative; Swelling; Trismus
• Interventions: Genetic: Leukocyte- and platelet-rich fibrin (L-PRF); Genetic: Advanced Platelet Rich Fibrin (A-PRF)

• Registration Number: NCT03672669
• Lead Sponsor: Near East University, Turkey

Brief Summary

In this study, it was aimed to investigating and comparing the postoperative effects of leukocyte- and platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF) in terms of pain, swelling on the cheek, and trismus after mandibular third molar surgery. The study included a total of 27 patients with bilateral impacted mandibular third molar which surgically operated at different times. Patients were evaluated in two randomly separated groups. For the first group; A-PRF and for the second group; L-PRF was applied into the tooth socket. The outcomes variables were; pain, swelling, the number of analgesics taken, and trismus. These variables were also assessed on the basis of; 1st, 2nd, 3rd and 7th days following the operation.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-11-05
• Primary Completion: 2018-03-01
• Study Completion: 2018-05-20
• Status Verified: 2018-09
• Study First Submitted: 2018-09-11
• Study First Submitted QC: 2018-09-13
• Last Update Submitted: 2018-09-13
• Study First Posted: 2018-09-14
• Last Update Posted: 2018-09-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 27

Inclusion Criteria

• age≥18
• the presence of bilaterally symmetrically impacted mandibular third molar, which requires an extraction for prophylactic reasons
• absence of systemic diseases
• absence of chronic opioid taken;
• not being pregnant
• not smoking and no alcohol usage
• the absence of allergy to penicillin or any other drugs used during standardized postoperative therapy.

Exclusion Criteria

• tooth needed to be sectioning during the operation
• operation time exceeding 30 minutes
• the cases with severe periodontal disease or acute pericoronitis,
• the cases using antibiotics for an existing infection
• the cases not capable of following postoperative instructions

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Leukocyte- and platelet-rich fibrin (L-PRF)	Leukocyte- and platelet-rich fibrin (L-PRF)	L-PRF was applied into the tooth socket after mandibular third molar surgery.
Advanced Platelet Rich Fibrin (A-PRF)	Advanced Platelet Rich Fibrin (A-PRF)	A-PRF was applied into the tooth socket after mandibular third molar surgery.

Primary Outcome Measures

Name	Time	Method
Pain Scores Evaluted	7th day after the operation.	For the postoperative period, the pain scores change was evaluated with the help of the visual analog scale (VAS) ranging from 0 (no pain) to 10 (most severe pain).

Secondary Outcome Measures

Name	Time	Method
Number of Analgesics Taken by the Patients	Each patient was evaluated on the 1st, 2nd, 3rd, and 7th days after the operation.
Trismus	Each patient was evaluated in order to obtain measurements on the 1st, 2nd, 3rd, and 7th days after the operation.	Trismus was assessed by measuring the distance between the mesioincisal corner of the maxillary and mandibular right incisors while mouth was fully opened
Swelling on the cheek	Each patient was evaluated in order to obtain measurements on the 1st, 2nd, 3rd, and 7th days after the operation.	In order to record swelling, a modification of the tape measurement method

Trial Locations

Locations (1)

Near East University; 🇹🇷 Mersin, Turkey