Comparison of the Effect of Advanced Platelet-rich Fibrin and Leukocyte- and Platelet-rich Fibrin on Outcomes After Removal of Impacted Mandibular Third Molar: A Randomised Split-mouth Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 27
- 试验地点
- 2
- 主要终点
- Pain Scores Evaluted
研究概览
简要总结
In this study, it was aimed to investigating and comparing the postoperative effects of leukocyte- and platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF) in terms of pain, swelling on the cheek, and trismus after mandibular third molar surgery. The study included a total of 27 patients with bilateral impacted mandibular third molar which surgically operated at different times. Patients were evaluated in two randomly separated groups. For the first group; A-PRF and for the second group; L-PRF was applied into the tooth socket. The outcomes variables were; pain, swelling, the number of analgesics taken, and trismus. These variables were also assessed on the basis of; 1st, 2nd, 3rd and 7th days following the operation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Supportive Care
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 26 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •the presence of bilaterally symmetrically impacted mandibular third molar, which requires an extraction for prophylactic reasons
- •absence of systemic diseases
- •absence of chronic opioid taken;
- •not being pregnant
- •not smoking and no alcohol usage
- •the absence of allergy to penicillin or any other drugs used during standardized postoperative therapy.
排除标准
- •tooth needed to be sectioning during the operation
- •operation time exceeding 30 minutes
- •the cases with severe periodontal disease or acute pericoronitis,
- •the cases using antibiotics for an existing infection
- •the cases not capable of following postoperative instructions
研究组 & 干预措施
Advanced Platelet Rich Fibrin (A-PRF)
A-PRF was applied into the tooth socket after mandibular third molar surgery.
干预措施: Advanced Platelet Rich Fibrin (A-PRF) (Genetic)
Leukocyte- and platelet-rich fibrin (L-PRF)
L-PRF was applied into the tooth socket after mandibular third molar surgery.
干预措施: Leukocyte- and platelet-rich fibrin (L-PRF) (Genetic)
结局指标
主要结局
Pain Scores Evaluted
时间窗: 7th day after the operation.
For the postoperative period, the pain scores change was evaluated with the help of the visual analog scale (VAS) ranging from 0 (no pain) to 10 (most severe pain).
次要结局
- Number of Analgesics Taken by the Patients(Each patient was evaluated on the 1st, 2nd, 3rd, and 7th days after the operation.)
- Trismus(Each patient was evaluated in order to obtain measurements on the 1st, 2nd, 3rd, and 7th days after the operation.)
- Swelling on the cheek(Each patient was evaluated in order to obtain measurements on the 1st, 2nd, 3rd, and 7th days after the operation.)
研究者
Mehmet Gagari Caymaz
Research Assistant
Near East University, Turkey