ISRCTN13970288进行中（未招募）Unknown
A randomised, placebo-controlled experimental study of dimethyltryptamine on alcohol reward memory in non-treatment-seeking excessive drinking: effects on drinking, therapeutic mechanisms and neural biomarkers
niversity College London0 个研究点目标入组 120 人开始时间: 2024年8月1日最近更新:
适应症
试验速览
- 阶段
- Unknown
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 120
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Aged 21 - 65 years
- •2. Normal or corrected-to-normal vision and hearing
- •3. Fluent English
- •4. Scoring >10 on the AUDIT questionnaire
- •5. Drinking =3 times a week
- •6. Drinking >20 UK units (160g etOH) per week for women or >35 UK units (280g etOH) per week for men; equivalent to = WHO ’moderate risk’ criteria
- •7. Motivated to reduce consumption based on the Motivation to Reduce Alcohol Consumption (MRAC) Scale
排除标准
- •1. Currently seeking or receiving treatment for alcohol use disorder (AUD) or other substance use disorders (SUDs)
- •2. Any current major mental health, neurological or physical health disorder
- •3. BMI <18 or >35 kg/m²
- •4. Severe alcohol dependence as assessed by Severity of Alcohol Dependence Questionnaire (SADQ)
- •5. Personal or family history of psychosis or schizophrenia
- •6. Personality disorder (assessed by Structured Assessment of Personality Abbreviated Scale [SAPAS] and clinical psychologist screening)
- •7. Lifetime trauma exposure (assessed by Stressful Life Events Screening Questionnaire [SLESQ])
- •8. >3 lifetime uses of DMT
- •9. Use of psychedelics within the past 6 months / any regular lifetime use
- •10. Regular use (> 2x /month) of psychoactive drugs other than nicotine, alcohol or caffeine
- •11. Contraindications to MRI
- •12. Known contraindication to psychedelic drugs
- •13. Current participation in other psychedelics or alcohol studies
- •14. Prior participation in similar studies within the UCL Clinical Psychopharmacology Unit
- •15. Previous familiarity with movies used in MRI scanning
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