nderstanding Neuroplasticity Induced by TrYptamines (UNITy): the effects of dimethyltryptamine (DMT) on drinking

Not Applicable

Active, not recruiting

• Conditions: Alcohol consumption, cue reactivity, craving and neural connectivity in non-treatment-seeking excessive (hazardous/harmful) alcohol drinking; Mental and Behavioural Disorders

• Registration Number: ISRCTN13970288
• Lead Sponsor: niversity College London

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-08-01
• Last Update Posted: 2024-08-19
• Study Completion: 2027-12-30

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

1. Aged 21 - 65 years
2. Normal or corrected-to-normal vision and hearing
3. Fluent English
4. Scoring >10 on the AUDIT questionnaire
5. Drinking =3 times a week
6. Drinking >20 UK units (160g etOH) per week for women or >35 UK units (280g etOH) per week for men; equivalent to = WHO ’moderate risk’ criteria
7. Motivated to reduce consumption based on the Motivation to Reduce Alcohol Consumption (MRAC) Scale

Exclusion Criteria

1. Currently seeking or receiving treatment for alcohol use disorder (AUD) or other substance use disorders (SUDs)
2. Any current major mental health, neurological or physical health disorder
3. BMI <18 or >35 kg/m²
4. Severe alcohol dependence as assessed by Severity of Alcohol Dependence Questionnaire (SADQ)
5. Personal or family history of psychosis or schizophrenia
6. Personality disorder (assessed by Structured Assessment of Personality Abbreviated Scale [SAPAS] and clinical psychologist screening)
7. Lifetime trauma exposure (assessed by Stressful Life Events Screening Questionnaire [SLESQ])
8. >3 lifetime uses of DMT
9. Use of psychedelics within the past 6 months / any regular lifetime use
10. Regular use (> 2x /month) of psychoactive drugs other than nicotine, alcohol or caffeine
11. Contraindications to MRI
12. Known contraindication to psychedelic drugs
13. Current participation in other psychedelics or alcohol studies
14. Prior participation in similar studies within the UCL Clinical Psychopharmacology Unit
15. Previous familiarity with movies used in MRI scanning

Study & Design

• Study Type: Interventional
• Study Design: Not specified