Functional Decline and Quality of Life in People Aging with HIV in Asia
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Frailty
- Sponsor
- Chinese University of Hong Kong
- Enrollment
- 1500
- Locations
- 1
- Primary Endpoint
- Functional disability
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
This is a multi-center prospective cross-sectional study to determine the burden of decline in intrinsic capacity and functional ability, and the prevalence of geriatric syndromes, such as frailty, and disability in adult people living with HIV (PLWH) in Asia.
Detailed Description
This research project is expected to have the following clinical impact 1. To understand the impact of impaired functional status in PLWH in Asia would be important to determine the long-term health burden needs in this aging population in this part of the world. 2. The identification of risk factors associated with impaired functional status would be important to guide clinical decisions in patient management, such as the choice of anti-retroviral regimen, and screening of and early intervention for modifiable risk factors. These are of paramount importance in the promotion of healthy aging in this population. 3. This proposed cross-sectional study lays the foundation for the establishment of a longitudinal cohort for long-term follow up of people aging with HIV in Asia, with the objectives of evaluating the long-term impact of aging on clinical outcomes and functional status in PLWH in this region.
Investigators
Shui-Shan Lee, MD
Professor
Chinese University of Hong Kong
Eligibility Criteria
Inclusion Criteria
- •HIV antibody positive
- •Age 35 years or above
- •Asian ethnicity, including but not limited to Chinese, Malay and Indian
Exclusion Criteria
- •Inability or refusal to consent
- •Active infections requiring in-hospital treatment
Outcomes
Primary Outcomes
Functional disability
Time Frame: 24 months
Functional disability is defined as any difficulty in any of the six areas of functioning in daily life as assessed by WHO DAS II questionnaire
Secondary Outcomes
- Cognitive decline(24 months)
- Frailty(24 months)
- Composite score for intrinsic capacity(24 months)
- Sarcopenia(24 months)
- Physical performance(24 months)
- Health-related quality of life(24 months)