The NoLA study
Recruiting
- Conditions
- analgesia, anesthesia, anaesthesia, peroperative, opioid consumption, nociception, monitoring.analgesie, anesthesie, perioperatief, pijn, nociceptie, opiaat consumptie,
- Registration Number
- NL-OMON28148
- Lead Sponsor
- eiden Univeristy Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 80
Inclusion Criteria
1. Age: 18-80 years;
2. ASA I-II-III
Exclusion Criteria
1. Unable to give written informed consent;
2. Use of epidural analgesia or local anesthesia (eg. transversus abdominal plain
block, TAP block)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Opioid and propofol consumption in total dose and dose/min; and<br /><br>2. Incidence (number of episodes) and total duration of inadequate anesthesia.
- Secondary Outcome Measures
Name Time Method 1. Differences in Pk (prediction probability) values of NoL, BIS, HR and MAP for<br>predicting the balance of nociception-anti nociception during the following<br>states<br /><br>• Awake vs. loss of consiousness (LOC)<br /><br>• Anesthesia (after discontinuation of propofol and remifentanil) vs. opening<br>eyes<br /><br>• LOC vs intubation<br /><br>• Normal stimulation vs maximum stimulation (as indicated by the surgeon);<br /><br>2. Incidence of NoL values < 10 and > 20;<br /><br>3. Time from reversal of neuromuscular blockade to extubation;<br /><br>4. Pain and sedation scores, incidence of nausea/vomiting, hemodynamics,<br>respiration and medication use (e.g. opioids and antiemetics) in the recovery<br>room obtained at 15-min interval;<br /><br>5. PACU: time until Aldrete > 9 (readiness for discharge);<br /><br>6. Incidence of memory/awareness.