Prevalence of Musculoskeletal Symptoms in the Cambridge NIHR BioResource
试验速览
- 阶段
- 不适用
- 入组人数
- 5,000
- 主要终点
- MSK Symptom Levels
研究概览
简要总结
Musculoskeletal diseases, such as osteoarthritis, represent a large proportion of the global burden of disease with hip and knee osteoarthritis alone being the 11th greatest cause of disease burden.
The purpose of this study is to determine the level of musculoskeletal symptoms in members of the Cambridge National Institute for Health Research (NIHR) BioResource and see if this is associated with their possession of genetic markers that have been identified as being associated with osteoarthritis.
This will allow us to determine the real level of musculoskeletal symptoms in this large cohort of volunteers and provide basic information that could be used to facilitate further musculoskeletal research in the NIHR BioResource population.
详细描述
All active members of the Cambridge NIHR BioResource will be approached.
They will be sent an email outlining the purpose of the study and asking that if they would like to take part to please complete the online questionnaire which will be linked to in the email.
For those individuals who agree to participate and complete the questionnaire, the Cambridge NIHR BioResource will provide the genetic marker information it already holds for specific markers that are known to be associated with osteoarthritis.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Member of the NIHR BioResource
- •Willing to consent to participate
排除标准
- •Previous self-report of osteoarthritis on joining BioResource
结局指标
主要结局
MSK Symptom Levels
时间窗: 3 months
Musculoskeletal Symptoms in respondents
Osteoarthritis genetic marker
时间窗: 6 months
Possession (or not) of specific genetic markers for osteoarthritis (obtained from information already held by the NIHR BioResource)
次要结局
- MSK Cohort(6 months)
研究者
Professor Andrew McCaskie
Professor of Orthopaedic Surgery / Head of Department
Cambridge University Hospitals NHS Foundation Trust