Trial of Bendamustine And Rituximab for Patients With Previously Untreated Extranodal Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma

Phase 2

Completed

• Conditions: MALT LYMPHOMA
• Interventions: Drug: Rituximab and Bendamustine

• Registration Number: NCT01015248
• Lead Sponsor: Grupo Español de Linfomas y Transplante Autólogo de Médula Ósea

Brief Summary

The aim of the study is to assess the therapeutic activity and safety of the combination of Bendamustine and Rituximab in MALT lymphomas.

Primary endpoint:

* Event-free-survival (EFS) (failure or death from any cause) for all patients.

Secondary endpoints:

* Complete and partial remission rates for all patients

* Response duration (time to relapse or progression) for responder patients

* Progression-free-survival (PFS) (disease progression or death from lymphoma: for all patients

* Overall survival for all patients

* Acute and long-term toxicity

Detailed Description

Not available

Study Timeline

• Study Start: 2009-05
• Study First Submitted: 2009-11-17
• Study First Submitted QC: 2009-11-17
• Study First Posted: 2009-11-18
• Primary Completion: 2013-12
• Study Completion: 2013-12
• Status Verified: 2016-09
• Last Update Submitted: 2016-09-06
• Last Update Posted: 2016-09-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Histologically proven diagnosis of CD20-positive marginal zone B-cell lymphoma of MALT type arisen at any extranodal site (WHO classification)

2. Any stage (Ann Arbor I-IV)

3. The novo disease en any extranodal site. For primary gastric or cutaneous lymphoma, local/specific previous treatment is accepted, just following the below criteria:

   1. Cutaneous lymphoma: recurrent lymphoma after local therapy
   2. Gastric lymphoma:

   b1. H. pylori-negative cases, either de novo (non pre-treated) or at relapse following local therapy (i.e., surgery, radiotherapy or antibiotics).

   b2. H. pylori-positive cases at diagnosis, who failed antibiotic therapy, including patients with: clinical (endoscopic) and histological evidence of disease progression at any time post H. pylori eradication; stable disease with persistent lymphoma at 1 year post H. pylori eradication; relapse (without H. pylori re-infection), after a remission; patients who failed either first line antibiotics or further local treatment (surgery or radiotherapy)

4. No evidence of histologic transformation to a high grade lymphoma

5. Measurable or evaluable disease

6. Age >18 and <85

7. ECOG performance status 0-2

8. Life expectancy of at least 1 year

9. Written informed consent given according to national/local regulations

Exclusion Criteria

1. Prior chemotherapy or prior immunotherapy with any anti-CD20 monoclonal antibody
2. Prior radiotherapy in the last 6 weeks
3. Corticosteroids during the last 28 days, unless prednisone chronically administered at a dose <20 mg/day for indications other than lymphoma or lymphoma-related symptoms
4. Major impairment of renal function (serum creatinine > 2,5 x upper normal) or liver function (ASAT/ALAT <2,5 x upper normal, total bilirubin <2,5x upper normal), unless due to lymphoma involvement.
5. Impairment of bone marrow function (WBC <3.0x109/L, ANC <1.5x109/L, PLT <100x109/L), unless due to lymphoma involvement
6. Evidence of clinically significant cardiac, neurological or metabolic disease, unless due to lymphoma involvement
7. Evidence of symptomatic central nervous system (CNS) disease
8. Active HBV and/or HCV infection
9. Known HIV infection
10. Prior diagnosis of neoplasm within 5 years, except cervical intraepithelial neoplasia type 1 (CIN1) or localized non-melanomatous skin cancer
11. Any psychiatric disease potentially hampering compliance with the study protocol and follow-up schedule
12. Potential to attend regular visits to the hospital, on an outpatient regimen
13. Hypersensibility to any compound of the study medication.
14. Non appropriate contraceptive method in women of childbearing potential or men
15. Treatment with any drug under research within 30 days previous to start the study medication.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Rituximab and Bendamustine	Rituximab and Bendamustine	-

Primary Outcome Measures

Name	Time	Method
The primary endpoint of assessment is the event-free-survival (EFS) according to the criteria of the International Workshop to Standardize Response Criteria for NHL and Criteria for evaluation of response in NHL	2 years follow-up

Secondary Outcome Measures

Name	Time	Method
Include evaluation of the next parameters: Complete and partial remission rates for all patients Response duration for responder patients PFS for all patients Overall survival for all patients Acute and long-term toxicity	2 years follow-up

Trial Locations

Locations (19)

Complejo Hospitalario Universitario de Santiago; 🇪🇸 Santiago de Compostela, La Coruña, Spain

Hospital Fundación Alcorcón; 🇪🇸 Alcorcón, Madrid, Spain

Hospital Son Llátzer; 🇪🇸 Palma de Mallorca, Mallorca, Spain

Hospital del Mar; 🇪🇸 Barcelona, Spain

Clínica Universitaria Navarra; 🇪🇸 Pamplona, Navarra, Spain

Hospital Universitario de Canarias; 🇪🇸 Sta. Cruz de Tenerife, Tenerife, Spain

Hospital MD Anderson; 🇪🇸 Madrid, Spain

Hospital La Princesa; 🇪🇸 Madrid, Spain

Hospital 12 de Octubre; 🇪🇸 Madrid, Spain

Hospital La Paz; 🇪🇸 Madrid, Spain

Hospital Universitario de Salamanca; 🇪🇸 Salamanca, Spain

Hospital Morales Meseguer; 🇪🇸 Murcia, Spain

Hospital Clínico de Zaragoza "Lozano Blesa"; 🇪🇸 Zaragoza, Spain

Hospital Ramón y Cajal; 🇪🇸 Madrid, Spain

ICO-Hospital Germans Trias i Pujol; 🇪🇸 Badalona, Barcelona, Spain

ICO-Hospital Durans i Reynals; 🇪🇸 Hospitalet de Llobregat, Barcelona, Spain

Hospital Marqués de Valdecilla; 🇪🇸 Santander, Cantabria, Spain

Hospital Central de Asturias; 🇪🇸 Oviedo, Asturias, Spain

Hospital Mutua de Terrassa; 🇪🇸 Terrassa, Barcelona, Spain