A Randomised, Clinical Trial of Corneal Collagen Cross-Linking in Keratoconus

Not Applicable

Active, not recruiting

• Conditions: keratoconus; Eye - Diseases / disorders of the eye

• Registration Number: ACTRN12613000143729
• Lead Sponsor: Royal Victorian Eye and Ear Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-02-06
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Active, not recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

At least one of the following criteria met over the preceding 12 months: an increase of at least 1 diopter in the steepest simulated keratometry reading derived from computerized videokeratography or in the steepest meridian measured by manual keratometry; an increase in astigmatism as determined by manifest subjective refraction of at least 1 diopter; or a 0.1mm or more decrease in back optic-zone radius of the best fitting contact lens

Exclusion Criteria

Minimum corneal thickness less than 400 microns; axial corneal scarring, previous refractive or other corneal surgery; a history of chemical burns; severe infections or other corneal or ocular surface disorders; patients who were pregnant or breastfeeding at the time of enrolment

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
maximum simulated keratometry value measured using computerised videokeratography (Orbscan II; Bausch and Lomb Surgical, Utah. Patients recruited after November 2007 were also imaged with Scheimplug imaging (Pentacam HR, Oculus, Germany)[5 years]