Asynchrony During Mechanical Ventilation in Patients With Acute Respiratory Distress Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 103
- 试验地点
- 5
- 主要终点
- Asynchrony rate
研究概览
简要总结
Asynchrony during mechanical ventilation has been poorly described in patients suffering from acute respiratory distress syndrome. The purpose of this study is to describe the frequency of asynchronies (ineffective efforts and double triggering) in these group and evaluate potential risk factors and prognosis implications.
详细描述
Major patient-ventilator asynchronies have been described during assisted mechanical ventilation in different settings. Few studies have evaluated double cycling in ARDS patient. No clear predictors of this finding beside low tidal volume have been found, and clinical outcome implications have not been addressed. This study has 3 main objectives: evaluate the frequency of double cycling and ineffective efforts, seek for potential predictors and clinical outcomes related to asynchronies. Subjects with less than 72 hours of mechanical ventilation due to ARDS will be recruited. Thirty minutes of mechanical ventilation will be recorded and automatically analyzed with a custom-made program to detect asynchronies. A blood sample will be drawn to measure inflammatory and lung tissue damage biomarkers. Clinical and outcome data will be recorded.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Acute Respiratory Distress Syndrome according to Berlin definition
- •Intubation and mechanical ventilation within 72 hours of inclusion
排除标准
- •Known severe neuromuscular disease
- •Continuous neuromuscular blocking agents infusion
结局指标
主要结局
Asynchrony rate
时间窗: 30 minutes
Asynchronies per minutes of mechanical ventilation
次要结局
- ICU mortality(From the date of admission to the date of discharge from the ICU, up to 90 days)
- Hospital mortality(From the date of admission to the date of discharge from the ICU, up to 90 days)
- Length of mechanical ventilation(From the date of intubation to the date of complete weaning from mechanical ventilation or death which ever comes first, up to 90 days)
研究者
Pablo Oscar Rodriguez
Assosiated Professor
Centro de Educación Medica e Investigaciones Clínicas Norberto Quirno