ext-Generation Sequencing (NGS) diagnostics of bacteremia in sepsis - Next GeneSiS-Trial

Klinik für Anästhesiologie, Universitätsklinikum Essen0 个研究点目标入组 500 人开始时间: 2017年10月9日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•- Informed consent
•Sepsis (with an onset =24h)
•-Patients with a life-threatening organ dysfunction caused by a dysregulated host response to a suspected or proven infection. Organ dysfunction can be identified as an acute change in total SOFA score =2 points consequent to the infection. Patients can also be promptly identified at the bedside with qSOFA, ie, alteration in mental status, systolic blood pressure =100mmHg, or respiratory rate =22/min.
•or Septic shock (with an onset =24h)
•-Patients with septic shock can be identified with a clinical construct of sepsis with persisting hypotension requiring vasopressors to maintain mean arterial pressure (MAP) =65mmHg and having a serum lactate level >2mmol/L (18mg/dL) despite adequate volume resuscitation

•- Age =18yr
•- Refusal to give consent
•- Patient will probably be discharged from the ICU within the first 72 hours following inclusion
•- Palliative treatment intent
•- Clinician is not committed to aggressive treatment
•- Death is deemed imminent and inevitable
•- Patients who had previously been included, but are readmitted to the ICU during the same hospitalization, will not be included a second time.

发起方

Klinik für Anästhesiologie, Universitätsklinikum Essen