KCT0000623
Recruiting
未知
A prospective, single-center, randomized study to evaluate the effect of sarpogrelate, a selective serotonin receptor antagonist, and high dose statin on the reduction of coronary spasm in the patients with variant angina
ConditionsDiseases of the circulatory system
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Diseases of the circulatory system
- Sponsor
- Samsung Medical Center
- Enrollment
- 200
- Status
- Recruiting
- Last Updated
- 7 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\) Age 20 \~ 70 years old
- •2\) Clinical history of chest pain compatible with variant angina; morning
- •chest pain aggravated by cold exposure.
- •3\) Angiographically proven coronary spasm; TIMI flow \< 3 by spontaneous
- •coronary spasm or intracoronary ergonovine spasm provocation test.
Exclusion Criteria
- •1\) Cardiac arrest by coronary spasm
- •2\) Left main coronary spasm
- •3\) Significant fixed coronary artery stenosis; Diameter stenosis \> 70% in the
- •major epicardial artery by coronary angiography
- •4\) LV ejection fraction \< 30%
- •5\) Coagulation disorders or bleeding tendency
- •(Platelet count \< 50k, PT INR \> 2\.0\)
- •6\) Significant liver disease (AST or ALT \> 100 U/ml)
- •7\) Renal failure (S\-Cr \> 2\.0 mg/dl)
- •8\) hypersensitivity for statin
Outcomes
Primary Outcomes
Not specified
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