Testing drugs for better pain relief in breast ontological studies

Phase 1

• Conditions: Health Condition 1: C509- Malignant neoplasm of breast of unspecified site

• Registration Number: CTRI/2020/12/029820
• Lead Sponsor: Sri guru ram das medical college

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

Female patients aged 20-70 yrs. with ASA grade I and II scheduled for elective Carcinoma breast surgeries.

2.Patients giving consent for the study.

Exclusion Criteria

Contraindications to epidural anaesthesia: Patients with spinal deformity, local infection, unstable hemodynamics, bleeding diathesis and on anticoagulants.

2. Contraindication to study drug: Allergy, hypersensitivity, mental retardation, drug abuse, cardiac, respiratory, renal, thyroid, hepatic and CNS disorder.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
evaluate twenty four hour postoperative analgesic efficacy of magnesium sulphate 1mg/kg vs ketamine 0.5 mg/kg as adjunct to epidural ropivacaine alone in patients undergoing breast oncological surgery.Timepoint: On arrival in the recovery room, time will be counted as 0 hours and the patient will be evaluated for vitals, pain, side effects every 30 minutes for next 2 hours and later at 4, 6, 8, 10, 12, 24 hrs.

Secondary Outcome Measures

Name	Time	Method
Efficacy of Magnesium as adjunct to Ropivacaine on intensity of post operative pain using Numerical Rating Score. <br/ ><br>2)Efficacy of Ketamine as adjunct to Ropivacaine on intensity of post operative pain using Numerical Rating Score. <br/ ><br>3)Comparison the efficacy of ketamine and magnesium on intensity of post operative pain using NRS. <br/ ><br>Timepoint: On arrival in the recovery room, time will be counted as 0 hours and the patient will be evaluated for vitals, pain, side effects every 30 minutes for next 2 hours and later at 4, 6, 8, 10, 12, 24 hrs.