Emotional Proactive Brain Study in Adults With Autism Spectrum Condition
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 94
- 试验地点
- 1
- 主要终点
- Differences between autistic and typically developed participants in evoked potentials related to prediction mechanisms during visual processing
研究概览
简要总结
This project aims:
- to study behavioral and cerebral activity specificity (latency and amplitude of evoked potentials, time frequency maps and cerebral connectivity) in predictive process (top-down regulation) during visual recognition of static and dynamic stimuli in adults participants with autism spectrum conditions compared to typically developed participants.
- to study the relation between predictive process and autonomous response (heart activity and electrodermal activity)
- to explore potential sex differences between autistic males and females
详细描述
Once eligibility criteria would have been verified, information on the study will be given and non opposition of the participant will be collected.Then, the participant will be comfortably installed in order to pass the Landolt C task (visual acuity task) on a computer. If his vision is normal, electroencephalogram (EEG), electrocardiogram (ECG) and electrodermal activity (EDA) of participants, will be recorded during visual processing and recognition tasks. Stimuli will include emotional and non emotional pictures and films, filtered in coarse-to-fine versus fine-to-coarse sequences in order to stimulate or not predictive process described by Bar (2007).
The participant will also have to complete an abbreviated version of the Wechsler Adult Intelligence Scale, IVth edition (Wechsler, 2003), and the Autism Spectrum Quotient (Baron-Cohen et al., 2001) if he never did it before. The aim is to pair as much as possible group by IQ and to verify that control participants don't present autistic traits above the Autism Spectrum Quotient cutoff. Groups will also be paired by age and education level.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •affiliation to the french social protection care
- •information and non opposition of the participant
- •information and non opposition of tutor/curator if the case presented
- •normal or corrected to normal vision
- •capacity to understand and apply instruction required by the task
- •no participation in another research
- •for autistic person: formal diagnosis of autism spectrum condition (autism/asperger/PDD-NS) according to CIM-10/DSM-IV/DSM-5 criteria
排除标准
- •adults with no ability to express their consent
- •adults on judiciary protection
- •perceptive/motor/neurological/psychiatric issue
- •major health issue (cardiac, metabolic ...)
- •alcohol or drug consumption
结局指标
主要结局
Differences between autistic and typically developed participants in evoked potentials related to prediction mechanisms during visual processing
时间窗: 55 minutes recording
- differences in evoked potentials (latency and amplitude) Changes will be assessed between coarse-to-fine and fine-to-coarse sequencies. It will be used to investigated how predictive mechanism during visual perception are affected in autism regarding cerebral activity.
Differences between autistic and typically developed participants in behavioral responses related to prediction mechanisms during visual processing
时间窗: 55 minutes (same recording as before)
- differences in behavioral responses (reaction time and correct response rate) Changes will be assessed between coarse-to-fine and fine-to-coarse sequencies. It will be used to investigated how predictive mechanism during visual perception are affected in autism regarding behavioral response.
次要结局
- Differences between groups in autonomous activity(55 minutes (same record as before))
- Sex differences(55 minutes (same record as before))
- Difference between groups in cerebral connectivity(55 minutes (same record as before))
- Differences between groups in oscillatory activity(55 minutes (same record as before))