National Registry of Hepatic Metastases From Non-Colorectal Cancer"

Completed

• Conditions: Non-colorectal Liver Metastasis; Liver Metastasis; Non-neuroendocrine Liver Metastasis; Liver Metastases; Non-colorectal Liver Metastases; Non-neuroendocrine Liver Metastases; Liver Resection; Hepatectomy

• Registration Number: NCT07180641
• Lead Sponsor: Clinica Universidad de Navarra, Universidad de Navarra

Brief Summary

The investigators designed this observational, retrospective, multicenter study including all patients who underwent surgery for non-colorectal liver metastases between January 2010 and December 2022, with the aim of establishing a series of recommendations for the treatment of liver metastases from various extrahepatic primary tumors

Detailed Description

Not available

Study Timeline

• Study Start: 2010-01-01
• Primary Completion: 2022-12-31
• Study Completion: 2022-12-31
• Study First Submitted: 2025-08-25
• Status Verified: 2025-09
• Study First Submitted QC: 2025-09-11
• Last Update Submitted: 2025-09-11
• Study First Posted: 2025-09-18
• Last Update Posted: 2025-09-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1039

Inclusion Criteria

• Patients scheduled for liver surgery due to non-colorectal liver metastases, regardless of the primary tumor origin, via open or minimally invasive approach

Exclusion Criteria

• Patients undergoing surgery for colorectal liver metastases, emergency surgical interventions and patients younger than 18 years old.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Overall Survival	5 years from liver resection	Time from the date of liver resection for non-colorectal metastases to death from any cause. Survival will be assessed for up to 5 years postoperatively
Progression-Free Survival	5 years from surgery	Time from the date of liver resection for non-colorectal metastases to the date of documented disease progression or death from any cause, whichever occurs first. Patients without progression or death will be censored at the last follow-up

Secondary Outcome Measures

Name	Time	Method
Postoperative Morbidity Rate	90 days from surgery	Incidence of any postoperative complications occurring within 90 days after liver resection, including but not limited to infections, bleeding, bile leaks, and other surgical complications, classified according to standard criteria.
Postoperative Mortality Rate	90 days from surgery	Proportion of patients who die from any cause within 90 days following liver resection surgery.
Recurrence Pattern	Up to 5 years from liver resection	Distribution and characterization of tumor recurrence (hepatic, extrahepatic, or both) after liver resection for non-colorectal metastases.
Length of hospital stay	Perioperative/Periprocedural	Number of days from surgery to discharge following liver resection
R0 Resection Rate	At surgery	Proportion of patients achieving complete microscopic liver tumor resection (R0) during liver resection