The Effect of Transcranial Direct Current Stimulation Intensity on Motor Performance in Healthy Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Change in movement time (s) from baseline to retention test
研究概览
简要总结
to investigate the effect of stimulation intensity on motor performance in healthy adults.
详细描述
60 healthy subjects were randomly allocated to one of three groups: (a) 20-min of High-Definition transcranial direct current stimulation (HD-tDCS) with an intensity of 2 mA (HD-tDCS 2 mA); (2) 20-min of HD-tDCS with an intensity of 1.5 mA (HD-tDCS 1.5 mA); and (3) 20-min of sham HD-tDCS (HD-tDCS sham). The stimulation was administered noninvasively using an M x N 9-channel high definition transcranial electrical current stimulator from Soterix Medical (New York, NY). The anodal stimulation targeted the right Brodmann area 4 (primary motor cortex) based on HD-Targets brain modelling software (Soterix Medical, New York, NY).
Tests: The non-dominant left arm was tested. The subjects performed a sequential point-to-point movement task on the graphics tablet. Initially, the participants were required to perform 3 sequences without errors to familiarize themselves with the setup, the task and the sequence. Then, they performed the pre-test which consisted of two blocks of 6 sequences, i.e. 12 sequences, with a 30 s break between blocks. Two min after starting the appropriate stimulation, they performed 2 blocks of 6 sequences (identical to the pre-test). After finishing the tDCS stimulation, the participants performed a post-test, which was also identical to the pre-test. The participants returned after 24 hours to perform a retention test, which was equivalent to the pre- and post-tests. Two outcome measures were used: movement time (s) and the reaction time (s) of the reaching movements.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •aged between 20 and 35
- •right-hand dominant
- •healthy according to self report
排除标准
- •taking psychiatric medications
- •a history of drug abuse or dependence
- •psychiatric or neurological disorder
- •a history of seizures
- •metal implants in their head
- •musculoskeletal deficits interfering with task performance (proper reaching performance in sitting)
研究组 & 干预措施
HD-tDCS 2 mA
Single session of 20-min HD-tDCS to the right primary motor cortex with an intensity of 2 mA. The session lasted approximately one hour. The participants returned after 24 hours to perform a retention test.
干预措施: HD-tDCS 2 mA (Device)
HD-tDCS 1.5 mA
Single session of 20-min HD-tDCS to the right primary motor cortex with an intensity of 1.5 mA. The session lasted approximately one hour. The participants returned after 24 hours to perform a retention test.
干预措施: HD-tDCS 1.5 mA (Device)
Control
Single session of 20-min of sham HD-tDCS. The session lasted approximately one hour. The participants returned after 24 hours to perform a retention test.
干预措施: HD-tDCS sham (Device)
结局指标
主要结局
Change in movement time (s) from baseline to retention test
时间窗: Baseline (immediately before stimulation), 24 hours following the stimulation
Time from movement onset (first time the tangential velocity was greater than 5% of the peak tangential velocity) until the end of the movement (the last time the tangential velocity was greater than 5% of the peak tangential velocity). Improved motor performance was indicated by a shorter movement time.
Change in reaction time (s) from baseline to intervention
时间窗: Baseline (immediately before stimulation), two minutes after starting the stimulation
Time between when the target appeared in green (changed color from white to green), and movement onset. Improved motor performance was indicated by a shorter reaction time.
Change in movement time (s) from intervention to posttest
时间窗: Two minutes after starting the stimulation, immediately post stimulation
Time from movement onset (first time the tangential velocity was greater than 5% of the peak tangential velocity) until the end of the movement (the last time the tangential velocity was greater than 5% of the peak tangential velocity). Improved motor performance was indicated by a shorter movement time.
Change in movement time (s) from intervention to retention test
时间窗: Two minutes after starting the stimulation, 24 hours following the stimulation
Time from movement onset (first time the tangential velocity was greater than 5% of the peak tangential velocity) until the end of the movement (the last time the tangential velocity was greater than 5% of the peak tangential velocity). Improved motor performance was indicated by a shorter movement time.
Change in movement time (s) from posttest to retention test
时间窗: immediately post stimulation, 24 hours following the stimulation
Time from movement onset (first time the tangential velocity was greater than 5% of the peak tangential velocity) until the end of the movement (the last time the tangential velocity was greater than 5% of the peak tangential velocity). Improved motor performance was indicated by a shorter movement time.
Change in reaction time (s) from baseline to retention test
时间窗: Baseline (immediately before stimulation), 24 hours following the stimulation
Time between when the target appeared in green (changed color from white to green), and movement onset. Improved motor performance was indicated by a shorter reaction time.
Change in reaction time (s) from intervention to posttest
时间窗: Two minutes after starting the stimulation, immediately post stimulation
Time between when the target appeared in green (changed color from white to green), and movement onset. Improved motor performance was indicated by a shorter reaction time.
Change in reaction time (s) from intervention to retention test
时间窗: Two minutes after starting the stimulation, 24 hours following the stimulation
Time between when the target appeared in green (changed color from white to green), and movement onset. Improved motor performance was indicated by a shorter reaction time.
Change in movement time (s) from baseline to posttest
时间窗: Baseline (immediately before stimulation), immediately post stimulation
Time from movement onset (first time the tangential velocity was greater than 5% of the peak tangential velocity) until the end of the movement (the last time the tangential velocity was greater than 5% of the peak tangential velocity). Improved motor performance was indicated by a shorter movement time.
Change in reaction time (s) from baseline to posttest
时间窗: Baseline (immediately before stimulation), immediately post stimulation
Time between when the target appeared in green (changed color from white to green), and movement onset. Improved motor performance was indicated by a shorter reaction time.
Change in movement time (s) from baseline to intervention
时间窗: Baseline (immediately before stimulation), two minutes after starting the stimulation
Time from movement onset (first time the tangential velocity was greater than 5% of the peak tangential velocity) until the end of the movement (the last time the tangential velocity was greater than 5% of the peak tangential velocity). Improved motor performance was indicated by a shorter movement time.
Change in reaction time (s) from posttest to retention test
时间窗: immediately post stimulation, 24 hours following the stimulation
Time between when the target appeared in green (changed color from white to green), and movement onset. Improved motor performance was indicated by a shorter reaction time.
次要结局
未报告次要终点