Efficacy of Celecoxib vs Placebo to Prevent Pain in a Paced Walk

Phase 4

Completed

• Conditions: Knee Osteoarthritis

• Registration Number: NCT00194090
• Lead Sponsor: University Hospitals Cleveland Medical Center

Brief Summary

A paced 20-minute walk is a reproducible model for acute pain in knee osteoarthritis

Detailed Description

This is a randomizd, placbo-controlled, crossover trial comparing a single dose of celecoxib to placebo measuring the time to onset of acute pain in a paced 20-minute walk.

40 subjects will be enrolled

Study Timeline

• Study Start: 2004-06
• Primary Completion: 2005-09-01
• Study Completion: 2005-09-01
• Study First Submitted: 2005-09-13
• Study First Submitted QC: 2005-09-13
• Study First Posted: 2005-09-19
• Status Verified: 2022-08
• Last Update Submitted: 2022-08-23
• Last Update Posted: 2022-08-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Knee osteoarthritis by ACR clinical criteria Pain of at least 40 mm by VAS at baseline

Exclusion Criteria

Non-pregant, non-lactating Able to stop active arthritis medication for washout Cardiovascular risk factors Abnormal EKG -

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
time to onset of severe pain

Secondary Outcome Measures

Name	Time	Method
time to onset of moderate pain

Trial Locations

Locations (1)

University Hospitals of Cleveland; 🇺🇸 Cleveland, Ohio, United States