An open labelled randomised comparative clinical and invitro study to evaluate the effect of Pashanabhedadi kashaya ghana capsule and Pashanabheda kashaya ghana capsule in the management of Mootrashmari vis-Ã -vis Nephrolithiasis

Background of the study:

Nephrolithiasis or calculi formation in kidneys, is a common problem worldwide,  with prevalence of 7% in the adults and > 30% recurrence  rate within 10years. The incidence  of Nephrolithiasis is globally increasing with an estimated prevalence ranging up to 15%. During lifetime, approximately 7% of women and 13% of men will develop a kidney stone. In Indian population, about 12% of them are expected to have urinary stones and  out of which 50% may end up loss of kidney functions. Invasive therapies for removal of calculi such as ESWL ( Extra corporeal shock wave  Lithotripsy). PCNL (Percutaneous nephrolithotripsy), Basketing therapy, Pylolithotomy are commonly for the management of Nephrolithiasis . Features of Nephrolithiasis are closely similar to the disease Mootrashmari in the Ayurveda parlance and majority of the pathology in both the condition are similar.

Purpose of the study:

In spite of technological advances in the field of  medicine and surgery conservative therapy still continues to a solution for all reversible ailments. Even though invasive therapies are one of the  alternatives used commonly for the management of Nephrolithiasis , however these therapies  have their  own disadvantages and complications. Kshara, kashaya  and churna  yogas  are frequently used  forms of medicines, palatability is major challenges. Considering the magnitude of the condition at present, there is a need of widely acceptable, evidence based, cost effective, easily available, simple, safe and single drug for Nephrolithiasis.