An open labelled randomised comparative clinical and in vitro study to evaluate the effect of Pashanabhedadi kashaya ghana capsule and Pashanabheda kashaya ghana capsule in the management of Mootrashmari vis-Ã -vis Nephrolithiasis
- Conditions
- Calculus of kidney,
- Registration Number
- CTRI/2023/05/053091
- Brief Summary
Background of the study:
Nephrolithiasis or calculi formation in kidneys, is a common problem worldwide, with prevalence of 7% in the adults and > 30% recurrence rate within 10years. The incidence of Nephrolithiasis is globally increasing with an estimated prevalence ranging up to 15%. During lifetime, approximately 7% of women and 13% of men will develop a kidney stone. In Indian population, about 12% of them are expected to have urinary stones and out of which 50% may end up loss of kidney functions. Invasive therapies for removal of calculi such as ESWL ( Extra corporeal shock wave Lithotripsy). PCNL (Percutaneous nephrolithotripsy), Basketing therapy, Pylolithotomy are commonly for the management of Nephrolithiasis . Features of Nephrolithiasis are closely similar to the disease Mootrashmari in the Ayurveda parlance and majority of the pathology in both the condition are similar.
Purpose of the study:
In spite of technological advances in the field of medicine and surgery conservative therapy still continues to a solution for all reversible ailments. Even though invasive therapies are one of the alternatives used commonly for the management of Nephrolithiasis , however these therapies have their own disadvantages and complications. Kshara, kashaya and churna yogas are frequently used forms of medicines, palatability is major challenges. Considering the magnitude of the condition at present, there is a need of widely acceptable, evidence based, cost effective, easily available, simple, safe and single drug for Nephrolithiasis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- All
- Target Recruitment
- 100
Diagnosed cases of Mootrashmari vis-Ã -vis Nephrolithiasis as per the diagnostic criteria Patients with solitary or multiple renal calculi with size less than or equal to 10 mile meter size Participants are willing to provide informed consent.
Patients with associated obstructive pathologies like BPH urethral stricture and congenital anatomical abnormalities Renal calculi in associated with uretreric bladder or uretral calculi During the phase of Renal colic and Ureteric colic Patients with severe Hydronephrosis Pregnant women and lactating mothers Systemic diseases which interfere with disease process and present clinical trial.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method EXPULTION OF KIDNEY STONES AT 45TH DAY
- Secondary Outcome Measures
Name Time Method IMPROVEMENT OF QUALITY OF LIFE based on a questionnaire
Trial Locations
- Locations (1)
SRI DHARMASTHALA MANJUNATHESHWARA COLLEGE OF AYURVEDA KUTHPADY UDUPI KARNATAKA
🇮🇳Udupi, KARNATAKA, India
SRI DHARMASTHALA MANJUNATHESHWARA COLLEGE OF AYURVEDA KUTHPADY UDUPI KARNATAKA🇮🇳Udupi, KARNATAKA, IndiaDR SHAILESH YPrincipal investigator08202520332drshayayu@gmail.com