Effects of Hookah (Waterpipe) Smoking on Blood Vessel Function

Not Applicable

Terminated

• Conditions: Hookah Smoking
• Interventions: Other: Hookah smoking

• Registration Number: NCT03616002
• Lead Sponsor: Cedars-Sinai Medical Center

Brief Summary

The purpose of this study is to assess the acute effects of Hookah (waterpipe) smoking on blood vessel function. Hookah smoking has been shown to immediately increase blood pressure and heart rate which could result in damage in the inner lining of the body's blood vessels.

Detailed Description

The investigators will measure acute endothelial and vascular changes before and after a 30-minute Hookah smoking session in a controlled laboratory environment to: (1) Determine the acute effects of Hookah smoking on large-vessel endothelial vasodilator function measured by brachial artery flow mediated dilation; (2) Determine the acute effects of Hookah smoking on micro-vessel endothelial function as measured by reactive hyperemia peripheral arterial tonometry; (3) Determine the acute effects of Hookah smoking on pulse wave velocity and aortic pressure waveform measured by pulse tonometry.

Study Timeline

• Study Start: 2015-01-01
• Study First Submitted: 2015-01-13
• Study First Submitted QC: 2018-08-02
• Study First Posted: 2018-08-06
• Primary Completion: 2020-03
• Study Completion: 2020-03
• Status Verified: 2021-02
• Last Update Submitted: 2021-02-02
• Last Update Posted: 2021-02-04

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 58

Inclusion Criteria

• 18 to 29 years of age
• Habitual Hookah smoker defined as having smoked Hookah >=12 times in the past 12 months
• Have not smoked cigarettes within the past 12 months

Exclusion Criteria

• History of cardiopulmonary, diabetes, dyslipidemia or psychiatric disease
• Exhaled carbon monoxide level >10 ppm
• BP < 140/90 mmHg
• BMI <18.5 or > 30 kg•m2
• Resting heart rate > 100 beats/min
• Taking prescription medication
• History of illicit drug use
• Pregnant

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Hookah smoking	Hookah smoking	Healthy habitual Hookah smokers will undergo brachial artery flow mediated dilation, reactive hyperemia peripheral arterial tonometry or pulse tonometry before and after Hookah smoking.

Primary Outcome Measures

Name	Time	Method
Brachial artery flow-mediated dilation	change from baseline to immediately after smoking

Secondary Outcome Measures

Name	Time	Method
Reactive hyperemia peripheral arterial tonometry	change from baseline to immediately after smoking

Trial Locations

Locations (1)

Cedars-Sinai Medical Center; 🇺🇸 Los Angeles, California, United States