Oxytocin Modulates the Processing of the Advantageous- and Disadvantageous-inequity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Behavioral index: fairness rating scores
研究概览
简要总结
The main aim of the study is to investigate whether intranasal oxytocin modulates advantageous- and disadvantageous-inequity and whether oxytocin has similar effects on them or not.
详细描述
The main aim of the study is to investigate whether intranasal oxytocin modulates advantageous- and disadvantageous-inequity and its underlying neural mechanisms and whether oxytocin has similar effects on them or not. A double-blinded, placebo-controled, between-subject design is employed in this study. In a randomized order, a total of 80 healthy males are instructed to self-administrated intranasal spray of oxytocin or placebo. A modified inequity decision-making task starts 45 minutes after treatment with behavioral (fairness rating, preference rating and the choice rate of unequal option) and fMRI data being collected during this task. Personality traits of subjects are assessed using validated Chinese version questionnaires including the Beck Depression Inventory (BDI-II), State-Trait Anxiety Inventory (STAI), Autism Spectrum Quotient (ASQ), Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSRQ), Behavioral Inhibition System and Behavioral Activation System Scale (BIS/BAS). Subjects are asked to complete Positive and Negative Affect Schedule (PANAS) when they just arrive, before and after the task.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy subjects without past or current psychiatric or neurological disorders
排除标准
- •history of head injury
- •pregnant,menstruating,taking oral contraceptives
- •medical or psychiatric illness.
- •excessive head movement (> 3mm) during scanning
研究组 & 干预措施
oxytocin
a single dose of 24 international units (IU) of OT will be administered with 3 puffs of treatment to each nostril.
干预措施: Intranasal oxytocin (Drug)
placebo
a single dose of 24 international units (IU) of placebo will be administered with 3 puffs of treatment to each nostril.
干预措施: Intranasal placebo (Drug)
结局指标
主要结局
Behavioral index: fairness rating scores
时间窗: 45-75 minutes after treatment administration
Participants are instructed to rate their perceived levels of fairness to the allocation using a 9-point Likert scale within 4 seconds (1 = very unfair, 9 = very fair).
Behavioral index: preference rating scores
时间窗: 45-75 minutes after treatment administration
Participants are instructed to rate their perceived levels of preference to the allocation using a 9-point Likert scale within 4 seconds (1 = not at all, 9 = very preferable).
Neural indices: fMRI-based measures of the outcome presentation stage
时间窗: 45-75 minutes after treatment administration
Functional magnetic resonance imaging (fMRI) is employed to assess participants' blood-oxygen-level dependent signals when they are confronted with monetary allocations (advantageous-inequity, disadvantageous-inequity, and fair).
次要结局
- Behavioral index: choice rate of unequal option(45-75 minutes after treatment administration)
- Neural indices: fMRI-based measures of outcome and re-decision stages(45-75 minutes after treatment administration)
研究者
Shuxia Yao
Professor
University of Electronic Science and Technology of China