ISRCTN88417663终止未知
Impact of CYP2C9 genotype and CYP2C9 inhibiting drugs on an individual’s metabolomics and metabolism of tolbutamide for interrogation of drug interactions
niversity of Dundee0 个研究点目标入组 6 人开始时间: 2021年5月21日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 终止
- 发起方
- 入组人数
- 6
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Aged 18 - 60 years
- •2. Caucasian (to limit genetic variation as much as possible)
- •3. Not known to have diabetes
- •4. No daily treatment with antidiabetic medication, statins, amitriptyline or other drugs that inhibit or require CYP2C9 or CYP3A4 metabolism
- •5. No cognitive impairment or visual impairment
- •6. Known CYP2C9 genotype – either normal (wild type”) or two reduced function alleles
排除标准
- •1. Heterozygous CYP2C9 genotype i.e. only one reduced function allele
- •2. Use of any antifungal drug within the last month
- •3. Recent involvement (<30 days) in a clinical trial
- •4. Pregnancy or planning to conceive
- •5. Inability/unwillingness to comply with the protocol
- •6. Anaemia
研究者
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