ISRCTN98608690已完成不适用
The effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute stroke: a phase II double-blind randomised placebo-controlled trial
Erasmus Medical Center (The Netherlands)0 个研究点目标入组 75 人开始时间: 2002年2月15日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 75
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •1. An acute ischaemic anterior circulation stroke
- •2. A body temperature greater than 36.0°C or less than 39.0°C
- •3. A CT scan that is compatible with acute ischaemic stroke
- •4. A focal deficit without rapid improvement
- •5. A possibility to start treatment within 24 hours after stroke onset
排除标准
- •1. Severe aphasia, defined as an aphasia score of 2 or 3 on the National Institutes of Health Stroke Scale (NIHSS)
- •2. Treatment with an non-Steroidal Anti-Inflammatory Drug (NSAID) deemed necessary
- •3. Hypersensitivity to ibuprofen or paracetamol
- •4. (Chronic) liver failure or cirrhosis
- •5. (Chronic) renal failure
- •6. History of alcohol abuse
- •7. Active gastric ulcer disease or a history of peptic ulceration or gastro-intestinal haemorrhage in the preceding year
- •8. Colitis ulcerosa
- •9. Pregnancy
- •10. Use of corticosteroids
- •11. A severe concomitant medical condition that could affect the assessment of the effect of the study medication on temperature
- •12. Residual neurological impairment resulting from a previous stroke that may hamper the assessment of functional outcome
- •13. Death appearing imminent
- •14. No informed consent given
研究者
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