Feedbacks' Influence on Decision Making Processes

Not Applicable

Completed

• Conditions: Healthy Volunteers
• Interventions: Other: mRI; Other: Effect of Galvanic Vestibular Stimulation on decision making processes

• Registration Number: NCT02816632
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

The purpose of this research is to identify and probe the neural networks involved in feedback processing. It aims at translating this knowledge to clinical populations in which this network is disrupted or compromised.

It includes two studies: 1) with fMRI in healthy subjects to identify the neural bases of feedback processing on decision making using different types of feedback (neutral, social and monetary) presented either infra- or supra-laminary and 2) probing the role of one structure, the anterior cingulate cortex, using Galvanic Vestibular Stimulation (GVS) in healthy subjects. The interventional part consists in the administration of Galvanic Vestibular Stimulation (GVS), which by means of small intensity currents activates the vestibular organs and subsequently vestibular-related brain areas. GVS will be delivered to healthy participants engaged in behavioural tasks requiring the processing of feedbacks of different nature (e.g. social or monetary feedbacks)

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2016-06-20
• Study First Submitted QC: 2016-06-24
• Study First Posted: 2016-06-28
• Study Start: 2017-03-30
• Primary Completion: 2019-09-18
• Study Completion: 2019-09-18
• Status Verified: 2022-02
• Last Update Submitted: 2022-02-22
• Last Update Posted: 2022-02-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 76

Inclusion Criteria

• Benefit of social health security
• Normal or corrected-to-normal vision

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Exclusion Criteria

• Anamnesis of neurological of psychiatric illness
• Pregnancy or breastfeeding
• Administrative measures restricting legal rights
• Epilepsy (including familiarity), migraines, chronic headaches
• presence of pacemakers, cochlear implants, surgical clips, or any metallic component fixed in participants' body
• Current treatment with psychotropic drugs
• Alcohol assumption during the last 24 hours
• Sleep deprivation
• Recent participation to other brain stimulation studies (< 1 week)

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
healthy volunteers	mRI	-
healthy volunteers	Effect of Galvanic Vestibular Stimulation on decision making processes	-

Primary Outcome Measures

Name	Time	Method
Behavioral performance (Reaction times)	up to 4 days	The proportion of reaction times provided, automatically computed by professional programs (e.g. Presentation) running on standard Personal Computers depending on different contexts (e.g. different feedback: neutral, social and monetary).
Behavioral performance (Accuracy)	up to 4 days	The proportion of correct responses, automatically computed by professional programs (e.g. Presentation) running on standard Personal Computers depending on different contexts (e.g. different feedback: neutral, social and monetary).

Secondary Outcome Measures

Name	Time	Method
Neural activity (BOLD signal measured using fMRI) as a function of the nature of the feedback.	up to 4 days	Neural activity changes during learning of visuomotor associations in different contexts (e.g. different feedback: neutral, social and monetary) measured using Blood-oxygen-level dependent contrast imaging (BOLD).

Trial Locations

Locations (1)

Unité de Neuro-Ophtalmologie Hôpital Neurologique - HOSPICES CIVILS DE LYON; 🇫🇷 Bron, France