Age-Related Hearing Loss: Presbycusis & Its Neural Bases
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 126
- 试验地点
- 2
研究概览
简要总结
The purpose of this study was to determine the effects of hormone replacement therapy (HRT) on hearing in post-menopausal women.
详细描述
Background: Female hormone influences on the development and aging of the auditory system are not completely understood. The present study retrospectively analyzed and compared hearing abilities among post-menopausal women taking hormone replacement therapy (HRT), treated with estrogen and progesterone (E+P); estrogen alone (E), and a third (control - NHRT) group, matched for age, who did not receive any HRT.
Methods: 126 subjects, (60-86 yr), N=32, E+P; N=31, E; N= 63, NHRT; matched for age and health status participated. All had relatively healthy medical histories, absence of significant noise exposure, middle ear problems, major surgeries or current/heavy smoking. Hearing tests included pure tone audiometry (PTA), tympanometry, distortion-product otoacoustic emissions (DPOAEs), transient otoacoustic emissions (TEOAEs) and hearing-in-noise-test (HINT). The latter is a test for speech perception in background noise: the major complaint of hearing-impaired persons.
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研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Other
入排标准
- 年龄范围
- 60 Years 至 86 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Healthy middle ears
排除标准
- •ototoxic medications
- •serious medical health problems
- •neurological conditions
- •Meniere's disease or labyrinthitis
- •those who failed cognitive screening tests (Mini-Mental Test)
- •current/heavy smokers
- •conductive hearing loss
- •history of noise damage and/or audiograms signifying noise damage
- •poor speech discrimination scores (80% or less)