South Australian Meningococcal B Vaccine Herd Immunity Study in Adolescents

Phase 4

Completed

• Conditions: Invasive Meningococcal disease; Neisseria meningitides nasopharyngeal carriage; Infection - Studies of infection and infectious agents; Public Health - Epidemiology

• Registration Number: ACTRN12617000079347
• Lead Sponsor: The University of Adelaide

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-01-16
• Study Completion: 2018-12-31
• Last Update Posted: 26 August 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 34489

Inclusion Criteria

1. South Australian secondary school students in years 10, 11, and 12 in 2017
2. Written parental consent for those under the age of 18
3. Written student consent-assent for those under the age of 18 (or if 18 years old and older consent for themselves)
4. Available at school for at least the first pharyngeal swab

Exclusion Criteria

1. Previous recipient of 4CMenB vaccine (Bexsero)
2. Known pregnancy
3. Anaphylaxis following any component of the 4CMenB vaccine

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence of all disease causing genogroups of N. meningitidis (A, B, C, W, X, Y) as measured by PCR at 12 months in vaccinated and unvaccinated year 10 and 11 school students. [One year after baseline visit]