Brain Heath Service for Prevention of AD
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 4,000
- 主要终点
- Identification of possible early AD
研究概览
简要总结
The aim of the program to serve as a prototype for future preventive program for AD in the region. The program will recruit elderly participants. Cognitive assessment and lifestyle questionnaire will be performed with each participant to investigator their risk factor associate with AD.
The program will offer medical referral and/or educational program(s) (e.g. tailor-made multidomain preventive measures plan, education talks) for participants who might have possible early AD or with high risk of AD
详细描述
Epidemiological studies over the past few decades demonstrate that AD is associated with multiple modifiable risk factors, including cardiovascular risk factors, level of physical and cognitively stimulating or social activities, and dietary pattern. Recent large scale randomized controlled clinical trials show that single- or multi-domain lifestyle intervention and control in cardiovascular risk factors can slow down cognitive decline among subjects with early AD who have suboptimal control in AD modifiable risk factors.
This study aims to identify subjects with possible early AD, to investigate the control in AD modifiable risk factors among subjects with early AD, and to implement tailor-made preventive measures among early AD subjects with suboptimal control in risk factors.
Through the BEAT AD program, knowledge on preventive measures of AD can be promoted around Hong Kong.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 55 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •1. Hong Kong citizens, between 55 - 80 years old.
排除标准
- •1. No known diagnosis of dementia or other diseases that may affect cognition, e.g., stroke, Parkinson's disease, brain infection, major head injury, major depression, obstructive sleep apnea, alcoholism (e.g., daily > 2 standard drinks for male and > 1 standard drinks for woman).
- •2. Subject who cannot understand Cantonese
研究组 & 干预措施
MCI
Mild Cognitive impaired
干预措施: medical referral and/or educational programs (Behavioral)
Healthy Control
Cognitive unimpaired
结局指标
主要结局
Identification of possible early AD
时间窗: At baseline
Using MoCA and retinal Image AD Index to screening participants who have high risk of Alzheimer's Disease
次要结局
- Investigation of the control in AD modifiable risk factors(At baseline)
- Implementation of AD preventive measures(End of educational program(s) approximately at 12 months and 24 months)
研究者
Vincent Mok
Professor
Chinese University of Hong Kong